About this Research Topic
Metabolic reprogramming significantly contributes to the progression and adaptability of cancer. The ability of cancer cells to alter their energy and intermediary metabolism allows them to proliferate and invade rapidly, supported by the dysregulated activity of metabolic enzymes. Mutations, transcriptional changes, and particularly post-translational modifications (PTMs) of these enzymes facilitate such metabolic shifts, with PTMs playing a pivotal role due to their swift and reversible nature. These modifications adapt metabolic processes to the dynamic intracellular and extracellular environments, engaging multiple metabolites in complex regulatory networks.
This research topic aims to elucidate the intricate relationships between post-translational modifications and cancer metabolic reprogramming. We focus on how PTMs like phosphorylation, lactylation, and ubiquitination influence metabolic enzymes’ activity, localization, and stability, and examine their collective impact on cancer cell fate. Delving into the various synergistic effects of these modifications will enhance our understanding of the mechanisms that govern cancer metabolism and progression.
To gather further insights into this complex field, we welcome articles addressing, but not limited to, the following themes:
• The roles of specific post-translational modifications (phosphorylation, lactylation, ubiquitination, etc.) in regulating metabolic enzymes in cancer.
• Interactions among different PTMs and their spatiotemporal influence on metabolic enzymes.
• Effects of inhibiting PTMs on metabolic enzymes in the progression of cancer.
• Mechanisms through which PTMs of metabolic enzymes aid cancer adaptation to stress conditions such as oxidative stress, nutritional deprivation, and chemotherapy responses.
This research topic aims to elucidate the intricate relationships between post-translational modifications and cancer metabolic reprogramming. We focus on how PTMs like phosphorylation, lactylation, and ubiquitination influence metabolic enzymes’ activity, localization, and stability, and examine their collective impact on cancer cell fate. Delving into the various synergistic effects of these modifications will enhance our understanding of the mechanisms that govern cancer metabolism and progression.
To gather further insights into this complex field, we welcome articles addressing, but not limited to, the following themes:
• The roles of specific post-translational modifications (phosphorylation, lactylation, ubiquitination, etc.) in regulating metabolic enzymes in cancer.
• Interactions among different PTMs and their spatiotemporal influence on metabolic enzymes.
• Effects of inhibiting PTMs on metabolic enzymes in the progression of cancer.
• Mechanisms through which PTMs of metabolic enzymes aid cancer adaptation to stress conditions such as oxidative stress, nutritional deprivation, and chemotherapy responses.
Keywords: Post-translational modifications, cancer, Metabolic reprogramming, Enzymatic activity, Protein degradation, Cancer adaptability
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
