Cell Models and Preclinical Validation of Immune-mediating Biological Therapies

  • 201

    Total views and downloads

Participate in this topic

About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 11 May 2025 | Manuscript Submission Deadline 24 September 2025

  2. This Research Topic is still accepting articles.

Background

Biological drugs, which include monoclonal antibodies, vaccines, recombinant and fusion proteins, cell and gene therapies, represent a rapidly evolving field in modern therapeutics. Many of these drugs are designed to modulate the immune system, a key aspect of treatment for a variety of diseases. Since the 1980s, biological drugs have transformed clinical practices in organ transplantation (muromonab), chronic immune conditions such as multiple sclerosis (interferon-beta) or Crohn’s disease (TNFα inhibitors) and cancer (interferon-alpha, immune checkpoint inhibitors). However, many challenges remain in treating resistant cancers and (auto)immune disorders, prompting the need for continued development of innovative immune-modulating therapies. Additionally, a significant share of patients does not response to the chosen therapy or lose response over time. This and the emerging plethora of novel therapies underpins the urgent need for reliable biomarkers to guide the selection of the best therapy for each patient. The progression from traditional 2D cell cultures to advanced 3D cell models has been transformative for drug testing, offering more complex and accurate representations of human tissues, while reducing the need for animal testing. 3D models, which better mimic the in vivo environment, provide enhanced predictive power for drug efficacy and are increasingly seen as essential tools in developing immune-modulating therapies.

The goal of this Research Topic is to highlight the latest advancements in immune-modulating biological drugs, with a focus on novel therapeutic approaches and the technologies driving their development. A key area of interest is the shift toward more complex and physiologically relevant in vitro models for drug testing, especially in the context of immune modulation. These models, including 3D cell cultures, co-culture and organ-on-chip systems, offer a significant improvement over traditional 2D models, providing a more accurate representation of the in vivo disease environment. Additionally, the aim is to explore how the integration of immune biomarkers can help personalize treatment approaches both in cancer and chronic immune diseases. By bringing together cutting-edge research on immune-modulating biologicals and the development of advanced cellular models, this special issue will contribute to a deeper understanding of the mechanisms of action and therapeutic potential of these emerging treatments.

This Research Topic welcomes original research papers and reviews addressing, but not limited to, the following themes:
- Novel immune-modulating agents and their therapeutic applications.
- Technological advancements in 3D cell culture systems and their impact on drug development.
- The role of immune biomarkers in customizing treatment plans.
- Comparative analysis of 2D and 3D drug testing methodologies.
- Clinical implications of novel biological therapies for treatment-resistant diseases. This special issue will provide a platform for disseminating research that bridges experimental innovations with clinical applications, ultimately contributing to more effective and personalized therapeutic strategies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Conceptual Analysis
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: cancer, immune chronic disease, biological drugs, 2D cell models, 3D cell models, biomarkers

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 201Topic views
View impact