The influence of probiotics on immune function has gained attention due to their role in modulating the gut microbiota, which interacts closely with the immune system. Emerging research reveals that probiotics can impact gene expression in immune cells, potentially affecting immune responses and overall health. However, the effects of probiotics on specific genetic mechanisms, including gene expression and allelic variability in immune cells, remain underexplored. Understanding these interactions at a genetic level is essential to optimize probiotic interventions for immune health and to reveal how probiotic strains influence immune cell function based on individual genetic backgrounds.

This Research Topic aims to explore the impact of probiotics on gene expression and allelic variants in immune cells, addressing critical gaps in our understanding of how probiotic strains influence immune responses at a molecular level. With advancements in multi-omics and genetic profiling, it is now possible to examine how specific probiotic strains modulate gene expression patterns and potentially interact with genetic polymorphisms that affect immune cell function. By investigating these interactions, researchers can uncover mechanisms by which probiotics support immune health, potentially leading to personalized probiotic treatments that consider individual genetic profiles. The goal is to encourage research that will not only clarify the immune-modulating properties of probiotics but also guide more precise therapeutic applications.

This Research Topic invites original research articles, reviews, and mini-reviews addressing the following themes:

• Impact of probiotics on gene expression profiles in immune cells (e.g., macrophages, T-cells, dendritic cells).
• Influence of probiotic strains on immune-related genetic polymorphisms and allelic variants.
• Probiotic-mediated modulation of inflammatory pathways and gene expression in immune cells.
• Role of host genetics in individual responses to probiotic interventions on immune health.
• Methods and technologies for assessing probiotic effects on immune gene expression and genetic variability.

We welcome studies using experimental, clinical, and computational approaches that provide insights into the genetic and immunological effects of probiotics.

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Frontiers in Immunology

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