About this Research Topic
All Diabetes, eg: abnormal glycemic control, involves four key pathophysiologic mechanisms that center around (result in) abnormal β-cell function: genetic changes, abnormal environment, inflammation, and insulin resistance (IR). Genetic interaction with external and internal environmental factors, including inflammation and IR, play a significant role, even in utero ( epigenetic changes ) leading to disease.
These same factors not only contribute to diabetes, and its complications, but also to cell and tissue damage across various associated conditions, notably, are linked to other conditions such as some cancers, dementia, psoriasis, ASCVD, NAFLD, and NASH. Increased risk for these conditions can occur before, with early, or overt abnormal glycemia/disease.
The concept of "Diabetes Syndrome" serves as a framework for understanding the interconnectedness of these conditions through shared pathophysiologies. Recognizing these associations can enhance patient care through prevention, early detection, and precision medicine. Additionally, it can drive advancements in education, research, and clinical practice, ultimately benefiting both patients and the medical field. This Research Topic therefore seeks to identify and explore these associations and seek to build the groundwork for new clinical solutions.
This collection invites researchers, clinicians, and healthcare professionals to contribute original research articles, reviews, perspectives and opinion pieces including but not limited to:
Pathophysiology Diabetes, complications, associated conditions
-Role of Inflammation in DS
-Role of Metabolic Syndrome in DS
-Prediabetes
-Beta-Cell function
-Including ‘Cure’, Reversal, Remission
-Oxidative Stress across DS
These same factors not only contribute to diabetes, and its complications, but also to cell and tissue damage across various associated conditions, notably, are linked to other conditions such as some cancers, dementia, psoriasis, ASCVD, NAFLD, and NASH. Increased risk for these conditions can occur before, with early, or overt abnormal glycemia/disease.
The concept of "Diabetes Syndrome" serves as a framework for understanding the interconnectedness of these conditions through shared pathophysiologies. Recognizing these associations can enhance patient care through prevention, early detection, and precision medicine. Additionally, it can drive advancements in education, research, and clinical practice, ultimately benefiting both patients and the medical field. This Research Topic therefore seeks to identify and explore these associations and seek to build the groundwork for new clinical solutions.
This collection invites researchers, clinicians, and healthcare professionals to contribute original research articles, reviews, perspectives and opinion pieces including but not limited to:
Pathophysiology Diabetes, complications, associated conditions
-Role of Inflammation in DS
-Role of Metabolic Syndrome in DS
-Prediabetes
-Beta-Cell function
-Including ‘Cure’, Reversal, Remission
-Oxidative Stress across DS
Keywords: glycemic control, diabetes, insulin resistance
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