About this Research Topic
This topic explores the diverse landscape of cell death mechanisms, emphasizing both regulated (non-apoptotic) and apoptotic pathways. We aim to provide an in-depth analysis of how these processes impact development, physiology, and disease, highlighting recent advances and future research directions.
Areas Covered:
1. Dynamics of Regulated Cell Death: Mechanistic insights into cell death types like necroptosis, ferroptosis, parthanatos, pyroptosis, and autophagic cell death during differentiation and development.
2. Mitochondrial and Cellular Stress Responses: Central roles of mitochondria and cellular homeostatic processes, including cell cycle regulation, ER quality control, and autophagy, in modulating cell death/survival.
3. Pathway Crosstalk and Immune Responses: Interactions between apoptosis and necrosis, and the role of regulated necrosis in the anti-cancer immune response or Non-apoptotic contributions to neurodegeneration through neuron-glia communication and inflammation.
4. Model Systems and Evolutionary Perspectives: Use of non-mammalian models to understand cell death evolution and lineage-specific regulation or novel tools for observing non-apoptotic deaths.
5. Therapeutic Applications and Innovations: Identification of new regulators and bioactive molecules targeting apoptosis or other cell death pathways in diseases like cancer and neurodegeneration or emerging strategies for leveraging omics data to devise targeted interventions.
This collection seeks full-length, mini, or systematic reviews that provide a holistic view of cell death pathways, enriching our understanding of their roles in health and disease, and guiding future therapeutic innovations
Areas Covered:
1. Dynamics of Regulated Cell Death: Mechanistic insights into cell death types like necroptosis, ferroptosis, parthanatos, pyroptosis, and autophagic cell death during differentiation and development.
2. Mitochondrial and Cellular Stress Responses: Central roles of mitochondria and cellular homeostatic processes, including cell cycle regulation, ER quality control, and autophagy, in modulating cell death/survival.
3. Pathway Crosstalk and Immune Responses: Interactions between apoptosis and necrosis, and the role of regulated necrosis in the anti-cancer immune response or Non-apoptotic contributions to neurodegeneration through neuron-glia communication and inflammation.
4. Model Systems and Evolutionary Perspectives: Use of non-mammalian models to understand cell death evolution and lineage-specific regulation or novel tools for observing non-apoptotic deaths.
5. Therapeutic Applications and Innovations: Identification of new regulators and bioactive molecules targeting apoptosis or other cell death pathways in diseases like cancer and neurodegeneration or emerging strategies for leveraging omics data to devise targeted interventions.
This collection seeks full-length, mini, or systematic reviews that provide a holistic view of cell death pathways, enriching our understanding of their roles in health and disease, and guiding future therapeutic innovations
Keywords: cell death, apoptosis, regulated cell death, mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
