About this Research Topic
Dr. Bruce Ames was a luminary in the fields of genetics and molecular biology, whose profound contributions have indelibly shaped our understanding of mutagenesis and the mechanisms underlying DNA repair. This Research Topic is dedicated to celebrating his pioneering work, particularly the development of the Ames test, which revolutionized the detection of mutagenic properties in chemical compounds with implications reaching across toxicology, pharmacology, and environmental sciences.
The Ames test, introduced in the early 1970s, provided an innovative, yet straightforward bacterial assay to assess the mutagenic potential of compounds, offering invaluable insights into chemical carcinogenesis. Dr. Ames’s contributions extended well beyond this test, encompassing extensive research into the molecular intricacies of mutagenesis and the cellular processes involved in DNA repair.
In honor of his remarkable legacy, this collection invites manuscript submissions that reflect the breadth of Dr. Ames's influence across various scientific domains. We particularly welcome contributions from past collaborators who can offer personal insights and detailed perspectives on the evolution of mutagenesis research. Additionally, submissions in the form of perspectives, opinions, and mini reviews are encouraged, aiming to explore both historical accomplishments and future directions stemming from Dr. Ames’s work.
Topics of interest include, but are not limited to:
• Advances in detecting and analyzing mutagenic compounds.
• Mechanistic insights into DNA repair processes.
• Evolutionary perspectives on mutagenesis and genetic stability.
• Applications and adaptations of the Ames test in modern research.
• The intersection of nutrition, genotoxicity, and metabolic regulation in human health.
• Advances in the triage theory of nutrition as a means of healthy aging.
This Research Topic aims to create a comprehensive tribute to Dr. Bruce Ames, fostering a collaborative space for reflection and innovation that continues to inspire future breakthroughs in molecular biosciences.
The Ames test, introduced in the early 1970s, provided an innovative, yet straightforward bacterial assay to assess the mutagenic potential of compounds, offering invaluable insights into chemical carcinogenesis. Dr. Ames’s contributions extended well beyond this test, encompassing extensive research into the molecular intricacies of mutagenesis and the cellular processes involved in DNA repair.
In honor of his remarkable legacy, this collection invites manuscript submissions that reflect the breadth of Dr. Ames's influence across various scientific domains. We particularly welcome contributions from past collaborators who can offer personal insights and detailed perspectives on the evolution of mutagenesis research. Additionally, submissions in the form of perspectives, opinions, and mini reviews are encouraged, aiming to explore both historical accomplishments and future directions stemming from Dr. Ames’s work.
Topics of interest include, but are not limited to:
• Advances in detecting and analyzing mutagenic compounds.
• Mechanistic insights into DNA repair processes.
• Evolutionary perspectives on mutagenesis and genetic stability.
• Applications and adaptations of the Ames test in modern research.
• The intersection of nutrition, genotoxicity, and metabolic regulation in human health.
• Advances in the triage theory of nutrition as a means of healthy aging.
This Research Topic aims to create a comprehensive tribute to Dr. Bruce Ames, fostering a collaborative space for reflection and innovation that continues to inspire future breakthroughs in molecular biosciences.
Keywords: Ames Test, mutagenesis, DNA repair, genetic toxicology, carcinogenesis, nutritional genomics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
