About this Research Topic
This Research Topic aims to publish research and review papers describing substantial scholarly contributions in the area of natural product research. Contributions shall deal with the use of naturally occurring bioactive compounds (polyphenols, phytosterols, carotenoids, essential fatty acids and essential oils) in the management of neurodegenerative disorders. Given that neurodegeneration is linked to various pathological processes, it’s important to adopt approaches that target multiple mechanisms of action. This includes strategies aimed at preventing cell death as well as revitalizing the function of injured neurons. We encourage the submission of studies describing the mechanistic aspects.
Neurodegenerative disorders are characterized through progressive loss of neuronal cells, which impacts their motor and cognitive functions. Most common neurodegenerative disorders include Alzheimer’s disease, followed by Parkinson’s disease, while others include multiple sclerosis, motor neuron disease and Huntington’s disease. Significant advances in our understanding of neurodegenerative diseases have been made, and we are resolute in overcoming the challenges of developing effective therapies. The use of natural products may provide potential opportunities for preventing and treating these disorders. Natural products derive from various biological sources, including bacteria, fungi, plants, marine life, and others, which include anti-oxidant properties extensively used in preventing and treating neurodegenerative disorders. These substances possess biological and pharmacological properties; some have been exploited as precursors for developing active pharmaceutical ingredients. A large volume of studies is underway to unravel newer bioactives in the field of neurodegenerative disorders. This special issue will include the recent advancements of such natural products presenting efficacy against neurodegenerative disorders.
This topic will cover the following topics:
• Neuroprotective activity of natural products
• Foods with antioxidant properties in neurodegenerative diseases
• Studies on interaction of natural products with cellular targets using computational approaches in combination with in vitro or in vivo studies
• Efficacy of natural bioactives in improving cognitive functions
• Clinical and preclinical studies of natural products in neurodegenerative diseases
• Strategies for enhancing the bioavailability of bioactives in the target region
• Natural products as metal-chelating agent in the management of metal induced neurodegenerative disorders
All contributions must follow the guidelines listed in this section:
- Please self-assess your manuscript using the ConPhyMP tool and follow the standards established in the ConPhyMP statement (Front. Pharmacol. 13:953205).
- Manuscripts must fully comply with the Four Pillars of Best Practice in Ethnopharmacology, ensuring the ethnopharmacological context is clearly described and the investigated material is characterized in detail.
- Purely in silico studies are outside of this journal’s scope
- The introduction must describe the topic’s background within an ethnopharmacological context and provide bibliographical references that illustrate the preparation’s application in traditional medicine or general healthcare.
Independent of the journal section selected for manuscript submission, all articles must comply with the guidelines above.
Neurodegenerative disorders are characterized through progressive loss of neuronal cells, which impacts their motor and cognitive functions. Most common neurodegenerative disorders include Alzheimer’s disease, followed by Parkinson’s disease, while others include multiple sclerosis, motor neuron disease and Huntington’s disease. Significant advances in our understanding of neurodegenerative diseases have been made, and we are resolute in overcoming the challenges of developing effective therapies. The use of natural products may provide potential opportunities for preventing and treating these disorders. Natural products derive from various biological sources, including bacteria, fungi, plants, marine life, and others, which include anti-oxidant properties extensively used in preventing and treating neurodegenerative disorders. These substances possess biological and pharmacological properties; some have been exploited as precursors for developing active pharmaceutical ingredients. A large volume of studies is underway to unravel newer bioactives in the field of neurodegenerative disorders. This special issue will include the recent advancements of such natural products presenting efficacy against neurodegenerative disorders.
This topic will cover the following topics:
• Neuroprotective activity of natural products
• Foods with antioxidant properties in neurodegenerative diseases
• Studies on interaction of natural products with cellular targets using computational approaches in combination with in vitro or in vivo studies
• Efficacy of natural bioactives in improving cognitive functions
• Clinical and preclinical studies of natural products in neurodegenerative diseases
• Strategies for enhancing the bioavailability of bioactives in the target region
• Natural products as metal-chelating agent in the management of metal induced neurodegenerative disorders
All contributions must follow the guidelines listed in this section:
- Please self-assess your manuscript using the ConPhyMP tool and follow the standards established in the ConPhyMP statement (Front. Pharmacol. 13:953205).
- Manuscripts must fully comply with the Four Pillars of Best Practice in Ethnopharmacology, ensuring the ethnopharmacological context is clearly described and the investigated material is characterized in detail.
- Purely in silico studies are outside of this journal’s scope
- The introduction must describe the topic’s background within an ethnopharmacological context and provide bibliographical references that illustrate the preparation’s application in traditional medicine or general healthcare.
Independent of the journal section selected for manuscript submission, all articles must comply with the guidelines above.
Keywords: Natural products, Metabolites, Natural compounds, Natural product research, Drug Discovery, Toxicology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
