About this Research Topic
Peri-implantitis and periodontitis are immune-inflammatory conditions driven by microbiota dysbiosis on oral surfaces. These diseases result from complex interactions between host immune responses and pathogenic microorganisms. The microbial communities within the periodontal microenvironment are regulated by intricate signaling systems influenced by host and environmental factors. Dysbiosis leads to immune system imbalances, triggering inflammation and tissue damage. The immune microenvironment, influenced by immune cells such as neutrophils, macrophages, and lymphocytes, plays a crucial role in disease pathogenesis. Dysregulation or overactivation of these cells disrupts immune homeostasis, exacerbating disease progression. Understanding the changes in immune responses and microbiota during these diseases is vital for developing innovative anti-inflammatory and regenerative strategies.
This Research Topic aims to provide a platform for researchers to share their latest findings and insights on immune microenvironment change during the pathogenesis of peri-implantitis and periodontitis. It will focus on the key immune cells, pathological processes, and microbiome interactions, highlighting novel observations, experimental findings, and innovative methods or therapies. The purpose of this collection is to clarify the regulatory mechanism of the local microenvironment. Novel strategies targeting these processes have both enhanced our understanding of pathogenic mechanisms of peri-implantitis and periodontitis and aided the design of innovative therapeutic approaches for oral disease prevention and treatment.
We welcome Original Research articles, Reviews, and Perspectives that address the following topics, including, but not limited to：
1. The pathogenic mechanism of microbiome on the development and progression of peri-implantitis and periodontitis.
2. Imbalance of immune response on the development and progression of peri-implantitis and periodontitis.
3. The role of microbiome interactions in peri-implantitis and periodontitis.
4. The characterization of the oral microbial community structure, diversity, and dynamics in periodontal and peri-implant diseases, using state-of-the-art techniques such as metagenomics, meta transcriptomics, and metabolomics.
5. The complex interplay between oral microbiota and host immune homeostasis in periodontal and peri-implant diseases.
This Research Topic aims to provide a platform for researchers to share their latest findings and insights on immune microenvironment change during the pathogenesis of peri-implantitis and periodontitis. It will focus on the key immune cells, pathological processes, and microbiome interactions, highlighting novel observations, experimental findings, and innovative methods or therapies. The purpose of this collection is to clarify the regulatory mechanism of the local microenvironment. Novel strategies targeting these processes have both enhanced our understanding of pathogenic mechanisms of peri-implantitis and periodontitis and aided the design of innovative therapeutic approaches for oral disease prevention and treatment.
We welcome Original Research articles, Reviews, and Perspectives that address the following topics, including, but not limited to：
1. The pathogenic mechanism of microbiome on the development and progression of peri-implantitis and periodontitis.
2. Imbalance of immune response on the development and progression of peri-implantitis and periodontitis.
3. The role of microbiome interactions in peri-implantitis and periodontitis.
4. The characterization of the oral microbial community structure, diversity, and dynamics in periodontal and peri-implant diseases, using state-of-the-art techniques such as metagenomics, meta transcriptomics, and metabolomics.
5. The complex interplay between oral microbiota and host immune homeostasis in periodontal and peri-implant diseases.
Keywords: Peri-implantitis, Periodontitis, Immune microenvironment, Oral microorganisms, Microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
