About this Research Topic
The tumor microenvironment (TME) is a complex ecosystem surrounding cancer cells, comprising various cellular components, extracellular matrix, and signaling molecules. Mounting evidence underscores the crucial role of the tumor microenvironment (TME) in shaping the molecular and biological characteristics of brain tumors. This special issue aims to elucidate the intricate interplay between the TME and brain tumors, uncover underlying mechanisms, and identify novel therapeutic targets.
We cordially invite submissions in the following formats: original research articles, comprehensive review papers, and expert opinion pieces. The scope of this topic included, but not limited to:
1. TME Composition and Function in Brain Tumors: Investigating the roles and interactions of different cell types (such as cancer-associated fibroblasts, immune cells), extracellular matrix, and signaling molecules in the brain tumor microenvironment.
2. TME and Brain Tumor Progression: Examining how the TME influences the growth, invasion, metastasis, and therapeutic resistance of brain tumors.
3. Immune Responses in the TME: Studying immune evasion mechanisms within the brain tumor microenvironment, as well as the applications and challenges of immunotherapy in brain tumors.
4. TME and Treatment Response: Analyzing how the TME affects the response of brain tumor patients to conventional therapies (such as radiotherapy and chemotherapy) and novel treatments (such as targeted therapy and immunotherapy).
5. Emerging Technologies and Methods: Introducing new technologies and methods in TME research, such as single-cell sequencing, spatial transcriptomics, and establishing novel prognostic models using bioinformatics analysis.
We cordially invite submissions in the following formats: original research articles, comprehensive review papers, and expert opinion pieces. The scope of this topic included, but not limited to:
1. TME Composition and Function in Brain Tumors: Investigating the roles and interactions of different cell types (such as cancer-associated fibroblasts, immune cells), extracellular matrix, and signaling molecules in the brain tumor microenvironment.
2. TME and Brain Tumor Progression: Examining how the TME influences the growth, invasion, metastasis, and therapeutic resistance of brain tumors.
3. Immune Responses in the TME: Studying immune evasion mechanisms within the brain tumor microenvironment, as well as the applications and challenges of immunotherapy in brain tumors.
4. TME and Treatment Response: Analyzing how the TME affects the response of brain tumor patients to conventional therapies (such as radiotherapy and chemotherapy) and novel treatments (such as targeted therapy and immunotherapy).
5. Emerging Technologies and Methods: Introducing new technologies and methods in TME research, such as single-cell sequencing, spatial transcriptomics, and establishing novel prognostic models using bioinformatics analysis.
Keywords: The tumor microenvironment, Brain Tumors, Immune Responses, Single-cell Sequencing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
