About this Research Topic
Regenerative medicine represents a transformative approach in healthcare, focusing on repairing or replacing damaged tissues and organs to restore normal function. Synthetic biology is revolutionizing the field of regenerative medicine by enabling the creation of smart biomaterials that not only support tissue regeneration but also actively participate in tissue repair and regeneration. These materials are characterized by their ease of engineering, excellent biosafety, and stimuli-responsiveness at target sites, which hold immense potential in applications such as connective tissue repair, bone regeneration, and the treatment of complex conditions like diabetic foot ulcers. Further, the integration of advanced fabrication techniques, such as 3D and 4D printing, with these smart materials further enhances their effectiveness, allowing for the creation of anatomically accurate and functionally dynamic constructs.
Despite the significant advances in smart biomaterials, the ultimate goal of precise and on-demand tissue regeneration remained as a daunting challenge in the field. One key issue is the development of materials that can closely mimic the complex biological environments of different tissues while also being adaptable to the dynamic conditions of the human body. The goal of this Research Topic is to explore innovative approaches to the design, fabrication, and application of smart biomaterials in regenerative medicine. Recent advancements in synthetic biology have spurred the development of a variety of bioinspired, polymer-based materials, such as protein coatings and ECM-like hydrogels. Notably, synthetic biology allows for the programming of biological systems at the genetic level, offering promising avenues for creating hybrid living materials that can respond to environmental stimuli. Additionally, the development of stimuli-responsive materials that change properties in response to specific triggers can lead to more effective and personalized treatments. By addressing these challenges, this Research Topic aims to advance the field toward the creation of next-generation biomaterials that can revolutionize tissue and organ regeneration.
This Research Topic invites contributions that explore the design, development, and application of smart biomaterials in regenerative medicine. We welcome submissions on the following themes: the use of synthetic biology in material design, the development of hybrid living materials, the creation of stimuli-responsive materials, and the application of these materials in connective tissue repair, organ regeneration, bone regeneration, and treatments for other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel disease (IBD). We encourage a variety of manuscript types, including original research articles, reviews, case studies, and perspectives that provide novel insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and propose new directions for the use of smart biomaterials in preclinical settings.
Despite the significant advances in smart biomaterials, the ultimate goal of precise and on-demand tissue regeneration remained as a daunting challenge in the field. One key issue is the development of materials that can closely mimic the complex biological environments of different tissues while also being adaptable to the dynamic conditions of the human body. The goal of this Research Topic is to explore innovative approaches to the design, fabrication, and application of smart biomaterials in regenerative medicine. Recent advancements in synthetic biology have spurred the development of a variety of bioinspired, polymer-based materials, such as protein coatings and ECM-like hydrogels. Notably, synthetic biology allows for the programming of biological systems at the genetic level, offering promising avenues for creating hybrid living materials that can respond to environmental stimuli. Additionally, the development of stimuli-responsive materials that change properties in response to specific triggers can lead to more effective and personalized treatments. By addressing these challenges, this Research Topic aims to advance the field toward the creation of next-generation biomaterials that can revolutionize tissue and organ regeneration.
This Research Topic invites contributions that explore the design, development, and application of smart biomaterials in regenerative medicine. We welcome submissions on the following themes: the use of synthetic biology in material design, the development of hybrid living materials, the creation of stimuli-responsive materials, and the application of these materials in connective tissue repair, organ regeneration, bone regeneration, and treatments for other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel disease (IBD). We encourage a variety of manuscript types, including original research articles, reviews, case studies, and perspectives that provide novel insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and propose new directions for the use of smart biomaterials in preclinical settings.
Keywords: Smart biomaterials, Synthetic biology, Regenerative medicine, Living therapeutics, Tissue regeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
