About this Research Topic
Metabolic disorders have emerged as a significant public health problem due to their rapidly increasing incidence and prevalence. Poor diet and sedentary lifestyle have contributed to a progression on the prevalence of metabolic disorders over the past two decades. Metabolic disorders encompass a group of disorders with the clustering of various interrelated pathological conditions combining obesity, metabolic dysfunction-associated fatty liver disease, hypertension, hyperglycemia, dyslipidemia, and diabetes. Together, these abnormalities strongly increase the incidence of cardiovascular diseases and elevate morbidity and mortality.
The gastrointestinal tract of animals harbors a complex and dynamic community of microorganisms, known as the gut microbiota. Ongoing studies have provided evidence of the beneficial and detrimental physiological effects of gut microbiota on host metabolic functions, including digestion and absorption of dietary nutrients, energy metabolism, glucose and lipid metabolism, and production of several vitamins and amino acids. In addition, gut microbiota contributes to the pathogenesis of chronic inflammation which is a potential risk factor in the development of metabolic disorders. Furthermore, a substantial body of findings revealed that the alterations in gut microbiota composition and function are associated with the increased incidence of metabolic disorders.
In this Research Topic, we aim to explore the crosstalk between gut microbiota and metabolic disorders and further identify potential metabolic disease-causing and disease-predicative microbial metabolite biomarkers.
This Research Topic welcomes Original Research articles and Reviews including, but not limited to the following subjects:
• Advances in the understanding of the association between gut microbiota and its metabolites in metabolic disorders.
• Novel potential metabolic disease-causing and disease-predicative microbial metabolite biomarkers.
• Potential microbiota-based interventions in preventing and alleviating metabolic disorders.
The gastrointestinal tract of animals harbors a complex and dynamic community of microorganisms, known as the gut microbiota. Ongoing studies have provided evidence of the beneficial and detrimental physiological effects of gut microbiota on host metabolic functions, including digestion and absorption of dietary nutrients, energy metabolism, glucose and lipid metabolism, and production of several vitamins and amino acids. In addition, gut microbiota contributes to the pathogenesis of chronic inflammation which is a potential risk factor in the development of metabolic disorders. Furthermore, a substantial body of findings revealed that the alterations in gut microbiota composition and function are associated with the increased incidence of metabolic disorders.
In this Research Topic, we aim to explore the crosstalk between gut microbiota and metabolic disorders and further identify potential metabolic disease-causing and disease-predicative microbial metabolite biomarkers.
This Research Topic welcomes Original Research articles and Reviews including, but not limited to the following subjects:
• Advances in the understanding of the association between gut microbiota and its metabolites in metabolic disorders.
• Novel potential metabolic disease-causing and disease-predicative microbial metabolite biomarkers.
• Potential microbiota-based interventions in preventing and alleviating metabolic disorders.
Keywords: gut microbiota, metabolites, metabolism, metabolic disorder, nutrition
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
