About this Research Topic
The immune system plays a crucial role not only in maintaining physiological balance but also in various pathological conditions. Understanding the molecular regulatory mechanisms of cell communication between immune cells and other non-immune components, such as stromal and parenchymal cells, is essential to unravel the complexity of inflammation and tumor progression. This Research Topic focuses on investigating the roles of these molecular interactions in diseases of the head and neck, oral cavity, gastrointestinal tract, and urogenital system, particularly in cancer. Elucidating these mechanisms will provide valuable insights into disease progression and offer new theoretical foundations for the development of therapeutic strategies and innovative drug targets.
By addressing these key areas, we aim to advance the understanding of the complex molecular interactions between immune cells and non-immune components. The findings from this Research Topic will provide new perspectives on the pathophysiology of inflammatory diseases and cancers and lay the foundation for future research and clinical applications.
Submissions to this Research Topic should address, but are not limited to, the following areas:
1. Immune Cell-Mediated Inflammation and Tumor Immune Responses: Explore the molecular mechanisms underlying immune cell-mediated inflammatory or tumor immune responses in benign and malignant diseases of the head and neck, oral cavity, and related systems. Detailed analysis of immune cell interactions within the tumor microenvironment and their influence on inflammation and tumor progression is encouraged. This includes the exploration of therapeutic agents targeting these mechanisms.
2. Cell Communication in Gastrointestinal and Hepatobiliary Diseases: Investigate the molecular regulatory mechanisms of cell communication between immune cells and parenchymal cells (e.g., squamous epithelial cells, gastrointestinal wall cells, hepatocytes, and biliary cells), as well as fibroblasts and vascular endothelial cells, in benign and malignant conditions of the esophagus, gastrointestinal tract, liver, and biliary system. Submissions may focus on how these complex signalling networks shape disease progression and the therapeutic potential of targeting these pathways.
3. Immune Mechanisms in the Reproductive and Urogenital Systems: Contributions should examine immune-mediated mechanisms of inflammation and tumor immunity in benign and malignant diseases of the prostate, kidney, uterus, ovaries, and other reproductive organs. Special focus is given to the dual role of the immune system in maintaining reproductive health and driving disease progression. Studies on novel therapeutic strategies based on these findings are welcome.
4. Immune Cell Function in Disease Progression and Therapy: This Research Topic welcomes studies on how immune cells contribute to the progression of various diseases, including cancer, or how they respond to drug treatments. Research may include immune cell function in different pathological contexts and the potential translational impact of these findings on clinical interventions.
By addressing these key areas, we aim to advance the understanding of the complex molecular interactions between immune cells and non-immune components. The findings from this Research Topic will provide new perspectives on the pathophysiology of inflammatory diseases and cancers and lay the foundation for future research and clinical applications.
Submissions to this Research Topic should address, but are not limited to, the following areas:
1. Immune Cell-Mediated Inflammation and Tumor Immune Responses: Explore the molecular mechanisms underlying immune cell-mediated inflammatory or tumor immune responses in benign and malignant diseases of the head and neck, oral cavity, and related systems. Detailed analysis of immune cell interactions within the tumor microenvironment and their influence on inflammation and tumor progression is encouraged. This includes the exploration of therapeutic agents targeting these mechanisms.
2. Cell Communication in Gastrointestinal and Hepatobiliary Diseases: Investigate the molecular regulatory mechanisms of cell communication between immune cells and parenchymal cells (e.g., squamous epithelial cells, gastrointestinal wall cells, hepatocytes, and biliary cells), as well as fibroblasts and vascular endothelial cells, in benign and malignant conditions of the esophagus, gastrointestinal tract, liver, and biliary system. Submissions may focus on how these complex signalling networks shape disease progression and the therapeutic potential of targeting these pathways.
3. Immune Mechanisms in the Reproductive and Urogenital Systems: Contributions should examine immune-mediated mechanisms of inflammation and tumor immunity in benign and malignant diseases of the prostate, kidney, uterus, ovaries, and other reproductive organs. Special focus is given to the dual role of the immune system in maintaining reproductive health and driving disease progression. Studies on novel therapeutic strategies based on these findings are welcome.
4. Immune Cell Function in Disease Progression and Therapy: This Research Topic welcomes studies on how immune cells contribute to the progression of various diseases, including cancer, or how they respond to drug treatments. Research may include immune cell function in different pathological contexts and the potential translational impact of these findings on clinical interventions.
Keywords: Immune cell communication, tumor microenvironment, inflammation, stromal cells, parenchymal cells, gastrointestinal diseases, reproductive health, cancer immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
