Lipids are fundamental components of cellular biology, serving as building blocks for cell membranes, energy storage molecules, and signaling mediators. Beyond these traditional roles, lipids have emerged as crucial regulators of immune cell function and metabolism. The field of immunometabolism, which explores the interplay between metabolic processes and immune responses, has revealed that lipids significantly influence immune cell activation, differentiation, and function.
In both health and disease, the metabolic pathways that generate, modify, and degrade lipids can impact the immune system. Dysregulated lipid metabolism has been linked to a variety of diseases, including obesity, diabetes, cardiovascular diseases, and autoimmunity. Understanding how lipids modulate immune responses provides unprecedented opportunities for developing novel therapeutic strategies to treat these conditions.
This Research Topic aims to deepen our understanding of the roles of lipids in immunometabolism by bringing together cutting-edge research and review articles. We seek contributions that investigate the molecular mechanisms by which lipids affect immune cell function, the impact of lipid metabolism on immune responses, and the clinical implications of lipid-immune interactions.We invite researchers to submit original research articles, brief research reports, reviews, and clinical studies focused on, but not limited to, the following sub-themes:
Lipid Signaling in Immune Cell Activation and Function: Exploration of the roles of lipid signaling molecules (e.g., eicosanoids, sphingolipids, and sterols) in the regulation of immune cell activation, differentiation, and effector functions.
Lipid Metabolism in Immune Cells: Studies on how metabolic pathways of lipid synthesis, modification, and degradation influence the function of different immune cell types, including macrophages, T cells, B cells, and dendritic cells.
Lipid Mediators in Inflammation and Resolution:Research on the roles of lipid-derived mediators in initiating, sustaining, and resolving inflammatory responses, as well as their implications for chronic inflammatory diseases.
Impact of Dietary Lipids on Immune Function: Investigation of how different types of dietary lipids and nutritional interventions affect immune cell metabolism and function, with potential implications for dietary recommendations and interventions in immune-related diseases.
Lipid Metabolism in Immune-Related Diseases: Examination of dysregulated lipid metabolism in the context of autoimmune diseases, metabolic syndrome, cardiovascular diseases, and cancer, and its impact on immune responses.
Therapeutic Targets and Interventions: Development and evaluation of therapies targeting lipid metabolic pathways to modulate immune responses and treat immune-related diseases.
Technological Advances in Lipidomics and Immunometabolism: Utilization of advanced lipidomics, metabolomics, and other omics technologies to unravel the complexity of lipid-immune interactions and identify novel biomarkers and therapeutic targets.
By assembling research across these areas, this topic aims to provide a comprehensive understanding of the complex roles of lipids in immunometabolism and to catalyze the development of innovative therapeutic approaches for treating immune-related diseases.
Keywords:
Lipids, Immunometabolism, Immune cell function, Lipid metabolism, Metabolic pathways, Immune responses, Lipid signaling, Inflammation, Lipid-derived mediators, Dietary lipids, Nutritional interventions, Autoimmune diseases, Metabolic syndrome
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Lipids are fundamental components of cellular biology, serving as building blocks for cell membranes, energy storage molecules, and signaling mediators. Beyond these traditional roles, lipids have emerged as crucial regulators of immune cell function and metabolism. The field of immunometabolism, which explores the interplay between metabolic processes and immune responses, has revealed that lipids significantly influence immune cell activation, differentiation, and function.
In both health and disease, the metabolic pathways that generate, modify, and degrade lipids can impact the immune system. Dysregulated lipid metabolism has been linked to a variety of diseases, including obesity, diabetes, cardiovascular diseases, and autoimmunity. Understanding how lipids modulate immune responses provides unprecedented opportunities for developing novel therapeutic strategies to treat these conditions.
This Research Topic aims to deepen our understanding of the roles of lipids in immunometabolism by bringing together cutting-edge research and review articles. We seek contributions that investigate the molecular mechanisms by which lipids affect immune cell function, the impact of lipid metabolism on immune responses, and the clinical implications of lipid-immune interactions.We invite researchers to submit original research articles, brief research reports, reviews, and clinical studies focused on, but not limited to, the following sub-themes:
Lipid Signaling in Immune Cell Activation and Function: Exploration of the roles of lipid signaling molecules (e.g., eicosanoids, sphingolipids, and sterols) in the regulation of immune cell activation, differentiation, and effector functions.
Lipid Metabolism in Immune Cells: Studies on how metabolic pathways of lipid synthesis, modification, and degradation influence the function of different immune cell types, including macrophages, T cells, B cells, and dendritic cells.
Lipid Mediators in Inflammation and Resolution:Research on the roles of lipid-derived mediators in initiating, sustaining, and resolving inflammatory responses, as well as their implications for chronic inflammatory diseases.
Impact of Dietary Lipids on Immune Function: Investigation of how different types of dietary lipids and nutritional interventions affect immune cell metabolism and function, with potential implications for dietary recommendations and interventions in immune-related diseases.
Lipid Metabolism in Immune-Related Diseases: Examination of dysregulated lipid metabolism in the context of autoimmune diseases, metabolic syndrome, cardiovascular diseases, and cancer, and its impact on immune responses.
Therapeutic Targets and Interventions: Development and evaluation of therapies targeting lipid metabolic pathways to modulate immune responses and treat immune-related diseases.
Technological Advances in Lipidomics and Immunometabolism: Utilization of advanced lipidomics, metabolomics, and other omics technologies to unravel the complexity of lipid-immune interactions and identify novel biomarkers and therapeutic targets.
By assembling research across these areas, this topic aims to provide a comprehensive understanding of the complex roles of lipids in immunometabolism and to catalyze the development of innovative therapeutic approaches for treating immune-related diseases.
Keywords:
Lipids, Immunometabolism, Immune cell function, Lipid metabolism, Metabolic pathways, Immune responses, Lipid signaling, Inflammation, Lipid-derived mediators, Dietary lipids, Nutritional interventions, Autoimmune diseases, Metabolic syndrome
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.