Emerging research in the field of pharmacoepigenetics is shedding light on how epigenetic modifications (such as DNA methylation, microRNAs, and histone acetylation) play a crucial role in regulating gene expression related to drug response. These epigenetic changes, which are influenced by a variety of environmental factors, including diet, lifestyle, and exposure to toxins, interact with genetic factors to shape an individual's response to medications. By investigating both genetic and epigenetic determinants, scientists aim to develop a deeper understanding of how different individuals react to the same drugs. This knowledge has the potential to significantly improve personalized medicine, allowing healthcare professionals to design more tailored and effective treatment plans. Instead of relying solely on a patient's genetic makeup, clinicians will be able to consider the dynamic influence of epigenetic modifications, which can change over time in response to external factors. This integrative approach could lead to more precise dosing, fewer adverse drug reactions, and better overall health outcomes, marking a significant advancement in the customization of medical care based on an individual's unique genetic and epigenetic profile.
This Research Topic aims to explore the role of epigenetic modifications in regulating the expression of genes involved in drug pharmacokinetics and pharmacodynamics, and to assess their complementary role alongside pharmacogenetic variants and phenoconversion. We seek to address the relationship between epigenetics and traditional drug response by (1) identifying regions of epigenetic variability, (2) pinpointing key epigenetic biomarkers within these regions, and (3) mapping these biomarkers to specific drug-response phenotypes. This approach builds on current knowledge to propose potential pharmacoepigenetic relationships, which can then be validated through experimental studies. Understanding how epigenetic factors influence the response to conventional drugs is crucial for optimizing drug design and administration, ultimately improving therapeutic outcomes and disease management.
We encourage authors to submit article types such as original studies, clinical cases, reviews, systematic reviews, and meta-analyses presenting findings related to epigenetic modifications on pharmacokinetics/pharmacodynamic genes influencing therapeutic effect, adverse drug events, or drug-drug interactions. The relationship between epigenetic modifications and pharmacogenetic variants are especially welcome. Preferred themes are:
• Pharmacoepigenetics/pharmacoepigenomic characterization of Populations
• Phenoconversion for epigenetic modifications
• The complementary role of epigenetic modifications with pharmacogenetic variants in therapeutic response.
• Pharmacoepigenomic predictive models for drugs.
• Bioinformatic modelling of epigenetic factors in pharmacokinetics/pharmacodynamic genes
Please note: If patient data are analyzed, a comprehensive description of the patients including sex, age, diagnostic criteria, inclusion and exclusion criteria, disease stage, therapy received, comorbidities as well as additional clinical information and assessment of clinical response/effects should be included. If genetic, proteomics, metabolomics, or other omics data are analyzed, a comprehensive description of the methods and the rationale for selecting the specific data studied should be provided. Studies related to natural compounds, herbal extracts, or traditional medicine products, are outside the scope of this Research Topic and should instead be submitted to the specialty section of Ethnopharmacology. Studies solely based on the analysis of public databases or published evidence, with no further experimental insights or insufficient experimental validation, will not be included in this Research Topic.
Keywords:
pharmacoepigenomics, epigenetics, epigenomics, personalized Medicine, pharmacoepigenetics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Emerging research in the field of pharmacoepigenetics is shedding light on how epigenetic modifications (such as DNA methylation, microRNAs, and histone acetylation) play a crucial role in regulating gene expression related to drug response. These epigenetic changes, which are influenced by a variety of environmental factors, including diet, lifestyle, and exposure to toxins, interact with genetic factors to shape an individual's response to medications. By investigating both genetic and epigenetic determinants, scientists aim to develop a deeper understanding of how different individuals react to the same drugs. This knowledge has the potential to significantly improve personalized medicine, allowing healthcare professionals to design more tailored and effective treatment plans. Instead of relying solely on a patient's genetic makeup, clinicians will be able to consider the dynamic influence of epigenetic modifications, which can change over time in response to external factors. This integrative approach could lead to more precise dosing, fewer adverse drug reactions, and better overall health outcomes, marking a significant advancement in the customization of medical care based on an individual's unique genetic and epigenetic profile.
This Research Topic aims to explore the role of epigenetic modifications in regulating the expression of genes involved in drug pharmacokinetics and pharmacodynamics, and to assess their complementary role alongside pharmacogenetic variants and phenoconversion. We seek to address the relationship between epigenetics and traditional drug response by (1) identifying regions of epigenetic variability, (2) pinpointing key epigenetic biomarkers within these regions, and (3) mapping these biomarkers to specific drug-response phenotypes. This approach builds on current knowledge to propose potential pharmacoepigenetic relationships, which can then be validated through experimental studies. Understanding how epigenetic factors influence the response to conventional drugs is crucial for optimizing drug design and administration, ultimately improving therapeutic outcomes and disease management.
We encourage authors to submit article types such as original studies, clinical cases, reviews, systematic reviews, and meta-analyses presenting findings related to epigenetic modifications on pharmacokinetics/pharmacodynamic genes influencing therapeutic effect, adverse drug events, or drug-drug interactions. The relationship between epigenetic modifications and pharmacogenetic variants are especially welcome. Preferred themes are:
• Pharmacoepigenetics/pharmacoepigenomic characterization of Populations
• Phenoconversion for epigenetic modifications
• The complementary role of epigenetic modifications with pharmacogenetic variants in therapeutic response.
• Pharmacoepigenomic predictive models for drugs.
• Bioinformatic modelling of epigenetic factors in pharmacokinetics/pharmacodynamic genes
Please note: If patient data are analyzed, a comprehensive description of the patients including sex, age, diagnostic criteria, inclusion and exclusion criteria, disease stage, therapy received, comorbidities as well as additional clinical information and assessment of clinical response/effects should be included. If genetic, proteomics, metabolomics, or other omics data are analyzed, a comprehensive description of the methods and the rationale for selecting the specific data studied should be provided. Studies related to natural compounds, herbal extracts, or traditional medicine products, are outside the scope of this Research Topic and should instead be submitted to the specialty section of Ethnopharmacology. Studies solely based on the analysis of public databases or published evidence, with no further experimental insights or insufficient experimental validation, will not be included in this Research Topic.
Keywords:
pharmacoepigenomics, epigenetics, epigenomics, personalized Medicine, pharmacoepigenetics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.