About this Research Topic

Background

Diseases with immune dysregulation occur when the immune system fails to function properly, either by being overactive, underactive, or attacking the body's own tissues. These disorders encompass a broad spectrum of conditions including autoimmune diseases, inborn errors of immunodeficiency, allergic conditions, autoinflammatory diseases and cancers. Public health authorities are reporting a global surge in these diseases, with African countries also witnessing a rise, marked by unique regional characteristics. African researchers are increasingly engaged in studying these conditions, reflecting a shift in the continent from infectious diseases to those involving immune dysregulation. However, the reality on the ground in these countries remains underexplored due to limited publication output, leaving significant gaps in our understanding.

This Research Topic addresses the challenges of diagnosing immune dysregulation diseases in Africa, with a particular emphasis on the region's unique epidemiological aspects. It delves into the immunological mechanisms underlying these diseases in African populations and highlights innovative therapeutic approaches designed to address their unique needs. By exploring these critical issues, the edition aims to provide insights into the specific challenges facing these regions and report on strategies that can improve disease management and patient outcomes in this context.

This Research Topic accepts Original Research, Systematic Review and Case Report. We welcome manuscripts focusing on, but not limited to, the following sub-topics:

• Molecular basis of inborn errors of immunity and specificities in Africa.

• The characterization of distinct allergens and prevalence of allergy among different African populations.

• Organ-specific and non- organ-specific autoimmune diseases.

• The epidemiological, immunochemical features and etiology of lymphoproliferative syndromes among different African populations.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Africa, allergy, autoimmunity, immune dysregulation, immunodeficiency, lymphoproliferative syndromes.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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