About this Research Topic
The complexity of the central nervous system (CNS) and its pathologies necessitates an intricate understanding of the cellular and molecular mechanisms at play. Single-cell biology has emerged as a powerful tool to dissect the heterogeneity and functional dynamics of individual cells within the CNS, offering unprecedented insights into the cellular landscape of various neurological disorders. This research topic aims to explore the latest advancements and applications of single-cell technologies in the study of CNS pathologies, including neurodegenerative diseases, neuroinflammatory conditions, and CNS injuries.
This Research Topic aims to address the critical need for advanced methodologies to study CNS pathologies at the single-cell level. By focusing on single-cell approaches, this research topic aims to bridge the gap between cellular heterogeneity and disease pathology, paving the way for more targeted and effective therapeutic strategies for CNS disorders. By bringing together cutting-edge research, this topic aims to foster collaborations and drive innovation in the field of cellular neuroscience.
This research topic invites original research articles, reviews, and methodological papers that highlight the application of single-cell technologies in CNS research. We seek contributions that provide novel insights into cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell findings.
Areas of interest include, but are not limited to:
• Single-Cell Transcriptomics in CNS Diseases:
o Profiling gene expression at the single-cell level to identify disease-specific cellular states and molecular pathways.
o Understanding the heterogeneity and plasticity of neuronal and glial cells in response to CNS pathologies.
• Single-Cell Epigenomics and Epitranscriptomics:
o Investigating epigenetic and epitranscriptomic modifications in individual CNS cells and their implications in disease progression and therapeutic resistance.
• Single-Cell Proteomics and Metabolomics:
o Deciphering protein expression patterns and metabolic alterations in single cells to uncover novel biomarkers and therapeutic targets.
• Spatial Single-Cell Omics:
o Integrating spatial transcriptomics and proteomics to map cellular interactions and microenvironments in the CNS during health and disease.
• Single-Cell Technologies in CNS Injury and Repair:
o Utilizing single-cell approaches to study cellular responses and regenerative processes following CNS injuries such as stroke and traumatic brain injury.
• Applications of Single-Cell CRISPR/Cas9 Screening:
o Employing single-cell CRISPR/Cas9 technologies to identify key regulators of cell function and survival in CNS pathologies.
• Single-Cell Multi-Omics Integration:
o Combining single-cell genomics, transcriptomics, proteomics, and metabolomics to achieve a comprehensive understanding of CNS disease mechanisms.
We encourage submissions that provide novel insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell findings.
Topic Editor Martin Valny is employed by Immunai. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
This Research Topic aims to address the critical need for advanced methodologies to study CNS pathologies at the single-cell level. By focusing on single-cell approaches, this research topic aims to bridge the gap between cellular heterogeneity and disease pathology, paving the way for more targeted and effective therapeutic strategies for CNS disorders. By bringing together cutting-edge research, this topic aims to foster collaborations and drive innovation in the field of cellular neuroscience.
This research topic invites original research articles, reviews, and methodological papers that highlight the application of single-cell technologies in CNS research. We seek contributions that provide novel insights into cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell findings.
Areas of interest include, but are not limited to:
• Single-Cell Transcriptomics in CNS Diseases:
o Profiling gene expression at the single-cell level to identify disease-specific cellular states and molecular pathways.
o Understanding the heterogeneity and plasticity of neuronal and glial cells in response to CNS pathologies.
• Single-Cell Epigenomics and Epitranscriptomics:
o Investigating epigenetic and epitranscriptomic modifications in individual CNS cells and their implications in disease progression and therapeutic resistance.
• Single-Cell Proteomics and Metabolomics:
o Deciphering protein expression patterns and metabolic alterations in single cells to uncover novel biomarkers and therapeutic targets.
• Spatial Single-Cell Omics:
o Integrating spatial transcriptomics and proteomics to map cellular interactions and microenvironments in the CNS during health and disease.
• Single-Cell Technologies in CNS Injury and Repair:
o Utilizing single-cell approaches to study cellular responses and regenerative processes following CNS injuries such as stroke and traumatic brain injury.
• Applications of Single-Cell CRISPR/Cas9 Screening:
o Employing single-cell CRISPR/Cas9 technologies to identify key regulators of cell function and survival in CNS pathologies.
• Single-Cell Multi-Omics Integration:
o Combining single-cell genomics, transcriptomics, proteomics, and metabolomics to achieve a comprehensive understanding of CNS disease mechanisms.
We encourage submissions that provide novel insights into the cellular and molecular mechanisms underlying CNS diseases, identify potential therapeutic targets, and discuss the translational potential of single-cell findings.
Topic Editor Martin Valny is employed by Immunai. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Keywords: single-cell biology, central nervous system, neurodegeneration, neuroinflammation, CNS injury, transcriptomics, epigenomics, proteomics, metabolomics, spatial omics, CRISPR/Cas9, multi-omics integration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
