About this Research Topic
Immunogenetics and organ transplantation have made significant progress in recent years. Genetic modification of organs, cells, and xenotransplants, effective utilization of registry data, innovative immunosuppressive approaches, and the development of kidney-paired donation (KPD) programs are about to transform clinical practice. The integration of artificial intelligence (AI) into these areas offers new opportunities for predictive analysis and personalized treatment.
The main objective of this research topic is to synthesize the latest advances in organ transplantation and immunogenetics by bringing together studies on transplant registries, xenotransplantation, cellular therapies, and promising new drugs. The focus will be on understanding how genetic modifications can overcome allograft and xenograft rejection and highlighting novel approaches that improve patient outcomes. KPD programs to overcome immunological incompatibility and AI-based data harmonization across transplant registries, providing insights into maximizing the benefits of shared information for the global transplantation effort, will be covered.
We welcome original research as well as review articles and case studies on the latest developments in immunogenetics and organ transplantation, including genetic modification of organs, regulatory therapies, prevention of ischemia-reperfusion injury, the role of autophagy, microbiome-based therapies, and use of transplant registry data with an emphasis on the use of AI in data harmonization and predictive modeling will be accepted. Xenotransplantation and genetic engineering techniques aimed at overcoming immunological rejection will be of interest. Regulatory cell therapies, along with desensitization strategies using promising new agents will also be covered.
Topic Editor Christian Morath is the founder and CSO of TolerogenixX GmbH. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The main objective of this research topic is to synthesize the latest advances in organ transplantation and immunogenetics by bringing together studies on transplant registries, xenotransplantation, cellular therapies, and promising new drugs. The focus will be on understanding how genetic modifications can overcome allograft and xenograft rejection and highlighting novel approaches that improve patient outcomes. KPD programs to overcome immunological incompatibility and AI-based data harmonization across transplant registries, providing insights into maximizing the benefits of shared information for the global transplantation effort, will be covered.
We welcome original research as well as review articles and case studies on the latest developments in immunogenetics and organ transplantation, including genetic modification of organs, regulatory therapies, prevention of ischemia-reperfusion injury, the role of autophagy, microbiome-based therapies, and use of transplant registry data with an emphasis on the use of AI in data harmonization and predictive modeling will be accepted. Xenotransplantation and genetic engineering techniques aimed at overcoming immunological rejection will be of interest. Regulatory cell therapies, along with desensitization strategies using promising new agents will also be covered.
Topic Editor Christian Morath is the founder and CSO of TolerogenixX GmbH. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Organ transplantation, immunogenetics, xenotransplantation, AI in transplantation, novel immunosuppressive agent, transplant registry, immunosuppressive cellular therapy, prevention of ischemia reperfusion injury
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