The endocrine milieu may regulate B and T cells responsiveness. Sex hormones execute several actions on T cells under physiological processes of non-reproductive tissues. Experimental models for autoimmune diseases have shown a marked pro-inflammatory role for certain hormonal factors and their receptors such as ER, PR, GR and PRL-R contributing to disease development. However, other endocrine factors have not been addressed at all, such as thyroid hormone receptors, dopamine receptors, and adrenergic receptors.
This research topic is aimed to shed light in how endocrine milieu, endocrine disruptors, endocrine genes, stress responses may modulate T cell biology with the main focus being on how T cell-mediated autoimmune responses may be affected by endocrine disruptors during different conditions including autoimmune diseases, gestation and lactation.
We welcome the submission of Original and Review articles addressing the scope of this collection where endocrine modulation of T and B cells are highlighted. Topics may include, but are not limited to:
• epigenetic profiling of endocrine genes in immune cells
• Sex-Steroids (Estrogens, Progesterone and Androgens) on T and B cell biology
• Stress response and glucocorticoids
• PRL, GH and Glucocorticoids on thymic development
• Thyroid hormones on DCs, T and B cell biology
• Epinephrine on T cells
• Homeostasis functions of T cells during development and Central Nervous System
• Immunity during lactation and gestation
Keywords:
T cell, B cell, autoimmunity, endocrine, hormone, glucocorticoid, thyroid hormone, prolactin, physiology
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The endocrine milieu may regulate B and T cells responsiveness. Sex hormones execute several actions on T cells under physiological processes of non-reproductive tissues. Experimental models for autoimmune diseases have shown a marked pro-inflammatory role for certain hormonal factors and their receptors such as ER, PR, GR and PRL-R contributing to disease development. However, other endocrine factors have not been addressed at all, such as thyroid hormone receptors, dopamine receptors, and adrenergic receptors.
This research topic is aimed to shed light in how endocrine milieu, endocrine disruptors, endocrine genes, stress responses may modulate T cell biology with the main focus being on how T cell-mediated autoimmune responses may be affected by endocrine disruptors during different conditions including autoimmune diseases, gestation and lactation.
We welcome the submission of Original and Review articles addressing the scope of this collection where endocrine modulation of T and B cells are highlighted. Topics may include, but are not limited to:
• epigenetic profiling of endocrine genes in immune cells
• Sex-Steroids (Estrogens, Progesterone and Androgens) on T and B cell biology
• Stress response and glucocorticoids
• PRL, GH and Glucocorticoids on thymic development
• Thyroid hormones on DCs, T and B cell biology
• Epinephrine on T cells
• Homeostasis functions of T cells during development and Central Nervous System
• Immunity during lactation and gestation
Keywords:
T cell, B cell, autoimmunity, endocrine, hormone, glucocorticoid, thyroid hormone, prolactin, physiology
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.