About this Research Topic
Vector-borne diseases contribute to approximately 17% of the global infectious disease burden and lead to over 700,000 deaths annually. Historically confined to tropical and subtropical regions, they are now expanding geographically, facilitated by vectors like mosquitoes, ticks, and sandflies that transmit pathogens- viruses, bacteria, or parasites—to their vertebrate hosts. This spread is due to various factors which affect the transmission dynamics and the outcomes of these infections. Recent research has focused on the role of the microbiome in modifying the transmission and infection through its interaction with both pathogen and host, presenting potential new avenues for disease control.
This Research Topic aims to consolidate current knowledge and promote further investigation into the microbiome's role within the context of vector-borne diseases. The emphasis is on understanding how microbiome interactions at various biological and ecological levels influence disease pathogenesis and could potentially lead to innovative therapeutic strategies. The overarching goal is to disclose the mechanisms through which the microbiome impacts pathogen development, host immune modulation, and ultimately, infection outcomes, thereby informing the development of novel control methods.
To gather further insights into the complex interplay between microbiomes and vector-borne diseases, we welcome articles addressing, but not limited to, the following themes:
• Crosstalk between Microbiome and Arthropod Hosts: Pathogen Development and Transmission;
• Role of vertebrate Microbiome in immune responses to pathogens and its virulence;
• Microbiome and Infection Outcomes in Endemic Regions;
• Impact of Microbiome on Prevention and Treatment Efficacy;
• Microbiome-based Interventions;
• Advanced Research Methods and AI-based Technologies.
These topics are intended to foster a deeper understanding of the microbiome's multifaceted role in disease dynamics through both fundamental and translational research approaches, leveraging advanced methodologies and cross-disciplinary collaborations.
The topic editors declare no conflicts of interest
This Research Topic aims to consolidate current knowledge and promote further investigation into the microbiome's role within the context of vector-borne diseases. The emphasis is on understanding how microbiome interactions at various biological and ecological levels influence disease pathogenesis and could potentially lead to innovative therapeutic strategies. The overarching goal is to disclose the mechanisms through which the microbiome impacts pathogen development, host immune modulation, and ultimately, infection outcomes, thereby informing the development of novel control methods.
To gather further insights into the complex interplay between microbiomes and vector-borne diseases, we welcome articles addressing, but not limited to, the following themes:
• Crosstalk between Microbiome and Arthropod Hosts: Pathogen Development and Transmission;
• Role of vertebrate Microbiome in immune responses to pathogens and its virulence;
• Microbiome and Infection Outcomes in Endemic Regions;
• Impact of Microbiome on Prevention and Treatment Efficacy;
• Microbiome-based Interventions;
• Advanced Research Methods and AI-based Technologies.
These topics are intended to foster a deeper understanding of the microbiome's multifaceted role in disease dynamics through both fundamental and translational research approaches, leveraging advanced methodologies and cross-disciplinary collaborations.
The topic editors declare no conflicts of interest
Keywords: Vector-borne diseases, Microbiome, Immune Response, Malaria, Leishmaniasis, Sleeping Sickness, American trypanosomiasis, Flaviviruses, Dengue, Zika, Yellow Fever, Infectious diseases, Virulence, Pathogen development, Transmission, Microbiota, Endemic regions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
