About this Research Topic
Liver diseases represent a significant global health challenge, encompassing a spectrum of conditions such as hepatitis, fatty liver disease, cirrhosis, and hepatocellular carcinoma. Recent advancements in epigenetics have shed light on the crucial role of epigenetic modifications in the pathogenesis and progression of liver diseases. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, play pivotal roles in regulating gene expression without altering the underlying DNA sequence. Understanding these mechanisms offers promising avenues for novel diagnostic markers and therapeutic targets, potentially transforming the management of liver diseases.
This research topic aims to highlight advances in epigenetic research by presenting cutting-edge studies and comprehensive reviews on the role of epigenetic modifications in liver disease. Bridging the gap between basic and clinical research by facilitating interdisciplinary dialogue between molecular biologists, geneticists and clinicians, translating epigenetic findings into clinical practice. Moreover, we will also seek innovative strategies targeting epigenetic modifications for the prevention, diagnosis, and treatment of liver diseases, promoting novel therapeutic approaches, and ultimately advancing the field of epigenetics in liver disease.
We welcome submissions of original research papers, reviews, data report, hypothesis & theory, methods, and opinions, including (but not limited to) research on the following sub-themes:
• The role of DNA methylation in liver disease progression and treatment.
• Histone modifications and their impact on liver disease gene expression.
• The function of non-coding RNAs in liver disease pathogenesis.
• Epigenetic biomarkers for early detection and prognosis of liver diseases.
• Therapeutic approaches targeting epigenetic modifications in liver diseases.
• Environmental and lifestyle factors influencing epigenetic modifications in liver health.
• Cross-talk between epigenetic modifications and other molecular pathways in liver diseases.
This research topic aims to highlight advances in epigenetic research by presenting cutting-edge studies and comprehensive reviews on the role of epigenetic modifications in liver disease. Bridging the gap between basic and clinical research by facilitating interdisciplinary dialogue between molecular biologists, geneticists and clinicians, translating epigenetic findings into clinical practice. Moreover, we will also seek innovative strategies targeting epigenetic modifications for the prevention, diagnosis, and treatment of liver diseases, promoting novel therapeutic approaches, and ultimately advancing the field of epigenetics in liver disease.
We welcome submissions of original research papers, reviews, data report, hypothesis & theory, methods, and opinions, including (but not limited to) research on the following sub-themes:
• The role of DNA methylation in liver disease progression and treatment.
• Histone modifications and their impact on liver disease gene expression.
• The function of non-coding RNAs in liver disease pathogenesis.
• Epigenetic biomarkers for early detection and prognosis of liver diseases.
• Therapeutic approaches targeting epigenetic modifications in liver diseases.
• Environmental and lifestyle factors influencing epigenetic modifications in liver health.
• Cross-talk between epigenetic modifications and other molecular pathways in liver diseases.
Keywords: Liver diseases, Epigenetics, Hepatitis, DNA methylation, Histone modifications, Non-coding RNAs, Gene expression, Epigenetic biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
