About this Research Topic
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases pose significant health challenges due to neuron loss and cognitive decline. While we understand the symptoms of these diseases, their underlying causes remain largely elusive. Utilizing two-dimensional (2D) and three-dimensional (3D) neuronal cultures derived from patient-specific stem cells, such as induced pluripotent stem cells (iPSCs), allows for the modeling of these pathologies not only at specific time points but throughout the entire differentiation process, mimicking, albeit with some limitations, in vivo onset of the disease.
While 2D systems offer simplicity, 3D counterparts, including organoids, better replicate brain complexity. Both models enable the investigation of molecular mechanisms underlying neurodegeneration, aiming to unveil pathways involved in these diseases and facilitate the identification of therapeutic targets and drug screening. These advancements promise deeper insights into disease mechanisms and the development of improved strategies for treating neurodegenerative diseases.
The goal of this Research Topic is to spotlight advancements in the understanding of molecular mechanisms driving various brain diseases through neurodegeneration, with a focus on utilizing patient-specific stem cell-derived models.
We invite submissions of original research articles or comprehensive reviews on the following topics:
- Pluripotent stem cell-derived cellular models of neurodegenerative disease: explore the latest advancements in stem cell-derived models to study neurodegenerative diseases such as but not limited to, Alzheimer’s, Parkinson’s, and Huntington’s disease.
- Omics analysis (transcriptomic, proteomic, metabolomic) of neurons, glial cells, or brain organoids derived from pluripotent stem cells affected by neurodegenerative diseases: present cutting-edge omics approaches applied to analyze gene expression, protein profiles, and metabolite signatures in neurons, glial cells, or brain organoids derived from pluripotent stem cells modeling neurodegenerative diseases.
- Identification of specific molecular pathways involved in neurodegeneration: focus on the elucidation of specific molecular pathways implicated in the pathogenesis of neurodegenerative diseases.
While 2D systems offer simplicity, 3D counterparts, including organoids, better replicate brain complexity. Both models enable the investigation of molecular mechanisms underlying neurodegeneration, aiming to unveil pathways involved in these diseases and facilitate the identification of therapeutic targets and drug screening. These advancements promise deeper insights into disease mechanisms and the development of improved strategies for treating neurodegenerative diseases.
The goal of this Research Topic is to spotlight advancements in the understanding of molecular mechanisms driving various brain diseases through neurodegeneration, with a focus on utilizing patient-specific stem cell-derived models.
We invite submissions of original research articles or comprehensive reviews on the following topics:
- Pluripotent stem cell-derived cellular models of neurodegenerative disease: explore the latest advancements in stem cell-derived models to study neurodegenerative diseases such as but not limited to, Alzheimer’s, Parkinson’s, and Huntington’s disease.
- Omics analysis (transcriptomic, proteomic, metabolomic) of neurons, glial cells, or brain organoids derived from pluripotent stem cells affected by neurodegenerative diseases: present cutting-edge omics approaches applied to analyze gene expression, protein profiles, and metabolite signatures in neurons, glial cells, or brain organoids derived from pluripotent stem cells modeling neurodegenerative diseases.
- Identification of specific molecular pathways involved in neurodegeneration: focus on the elucidation of specific molecular pathways implicated in the pathogenesis of neurodegenerative diseases.
Keywords: Neurodegenerative disorders, Alzheimer's disease, Parkinson's disease, Induced pluripotent stem cells (iPSCs), 2D neuronal cultures, 3D neuronal cultures, Brain organoids, Molecular mechanisms, Neurodegeneration models, Therapeutic targets
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