About this Research Topic

Background

Long Noncoding RNAs (LncRNAs) are proven to be critical in cancer biology playing a significant role in tumor formation and progression. In contrast to protein coding RNAs, lncRNAs can neither be translated into proteins but rather they exert their function through various pathways including epigenetic regulation, transcription, and post transcription. New research has revealed that lncRNAs are involved in different aspects of cancer mell include cell proliferation, apoptotic resistance, metastasis and resistance to therapy. Most of these molecules may function either as oncogenes or tumor suppressor genes based on their environment, and they therefore constitute attractive target for possible therapeutic intercessions. This knowledge of the functions and mechanisms of lncRNA in cancer could pave the way for new diagnostic, prognostic and therapeutic interventions of cancers, and also suggest that lncRNAs are hopeful for more effective and individualized cancer treatment.

The purpose of this Research Topic is to unravel the complexity of lncRNAs, their involvement in cancer and to consider them as diagnostic markers and targets for treatment. However, the extensive functions and molecular regulation of lncRNAs in these cancers are not well understood even though great progress has been made in this regard recently. It is imperative to establish how a particular lncRNA promotes cancer development, metastasis and chemoresistance. To this end, this research topic seeks to fill these gaps by promoting researches, which probe the molecular functions of lncRNAs, its associations with other biomolecules, as well as its influence on cellular processes that are associated with cancer advancement.
New techniques in high-throughput sequencing as well as fast-developing bioinformatics have made it possible to discover many novel lncRNAs related to cancer, which has created a great opportunity for more research. Thus, these enhance researchers’ ability to identify new and clinically relevant lncRNAs, promising the advent of lncRNA-based biomarkers and targeted therapies. This collection is intended to gather state-of-the-art studies that will improve our understanding of lncRNAs in cancer and help to implement them into the practice.

We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Regulation of lncRNAs in cancer development and progression.
• Roles of lncRNAs in metastasis and drug resistance.
• Identifying and validating lncRNAs as biomarkers for cancer diagnosis, prognosis, and therapy response.
• Therapeutic targeting of lncRNAs and their potential in personalized medicine.
• Integration of advanced methodologies, such as CRISPR-Cas9 gene editing, RNA sequencing, and bioinformatics, in lncRNA research.

Please note manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Long noncoding RNAs, Cancer Biology, Tumor progression, Biomarkers, Therapeutic targets

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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