About this Research Topic
The ongoing global health challenge posed by neglected tropical diseases (NTDs) and their often devastating intersections with pandemic diseases such as COVID-19 has highlighted critical gaps in our current therapeutic arsenal. Emerging data have underscored how coinfections can exacerbate severity and complicate the management of health crises, particularly in resource-limited tropical regions. The concern is further amplified by the growing resistance to multiple drugs, the variable efficacy of vaccines, the occurrence of viral mutations, and the subsequent global health implications. This situation highlights a stark need for innovative therapeutic solutions capable of addressing a broad spectrum of pathogens effectively.
Another concern will be the co-circulation of one of these infectious diseases and the comorbidity. Severe hospitalization cases and the high rate of mortality are mostly found in patients suffering an infectious disease and a comorbidity.
Therefore, this Research Topic aims to accelerate the discovery and development of natural products, together with their synthetic and semi-synthetic derivatives, as potential therapeutic agents. The focus extends to combating a diverse array of pathogens including, but not limited to, viruses like SARS and COVID-19, multidrug resistant bacteria, and protozoans responsible for diseases such as malaria, Chagas and leishmaniasis, and multimorbidity diseases. The objective is to harness the unique properties of these natural compounds in medicinal chemistry, leveraging their bioactivity to counteract both established and emerging infectious threats.
To gather further insights in the medicinal chemistry of natural products and their expanded role against infectious diseases and multimorbidity diseases, we welcome articles addressing, but not limited to, the following themes:
- Structural elucidation of natural products and their bioactivities.
- Impact of semi-synthetic and synthetic derivatives on antimicrobial resistance, and parasitic tropical pathogens.
- Natural and natural-derived compounds with their potential against multimorbidity diseases such as cardiovascular diseases, high blood pressure, diabetes, obesity and other diseases.
- LCMS analysis and biological evaluation of medicinal plant extracts.
- Studies detailing the antipathogenic mechanisms of natural products and their derivatives.
- Rational design and synthesis of natural product analogues for enhanced antimicrobial and antiprotozoal activities.
- Well characterized herbal formulation and their antimicrobial, antiprotozoal, antidiabetic, and anti-obesity activities.
- Anti-infectious effect insights from marine, fungal, mushrooms, and bacterial sources of natural products.
Another concern will be the co-circulation of one of these infectious diseases and the comorbidity. Severe hospitalization cases and the high rate of mortality are mostly found in patients suffering an infectious disease and a comorbidity.
Therefore, this Research Topic aims to accelerate the discovery and development of natural products, together with their synthetic and semi-synthetic derivatives, as potential therapeutic agents. The focus extends to combating a diverse array of pathogens including, but not limited to, viruses like SARS and COVID-19, multidrug resistant bacteria, and protozoans responsible for diseases such as malaria, Chagas and leishmaniasis, and multimorbidity diseases. The objective is to harness the unique properties of these natural compounds in medicinal chemistry, leveraging their bioactivity to counteract both established and emerging infectious threats.
To gather further insights in the medicinal chemistry of natural products and their expanded role against infectious diseases and multimorbidity diseases, we welcome articles addressing, but not limited to, the following themes:
- Structural elucidation of natural products and their bioactivities.
- Impact of semi-synthetic and synthetic derivatives on antimicrobial resistance, and parasitic tropical pathogens.
- Natural and natural-derived compounds with their potential against multimorbidity diseases such as cardiovascular diseases, high blood pressure, diabetes, obesity and other diseases.
- LCMS analysis and biological evaluation of medicinal plant extracts.
- Studies detailing the antipathogenic mechanisms of natural products and their derivatives.
- Rational design and synthesis of natural product analogues for enhanced antimicrobial and antiprotozoal activities.
- Well characterized herbal formulation and their antimicrobial, antiprotozoal, antidiabetic, and anti-obesity activities.
- Anti-infectious effect insights from marine, fungal, mushrooms, and bacterial sources of natural products.
Keywords: Natural Products, Antimicrobial Properties, Synthetic Derivatives, Broad spectrum of pathogens
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
