Gut Mediated Regulation of Cellular Therapies: Challenges and Opportunities

  • 131

    Total Views and Downloads

Participate in this topic

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 28 January 2025 | Manuscript Submission Deadline 18 May 2025

  2. This Research Topic is still accepting articles.

    1. Check author guidelines

Background

Cellular therapies using CAR-T cells or tumor-infiltrating lymphocytes (TILs) are promising anti-cancer approaches, especially in haematological malignancies. The responses to CAR-T cell therapy and TIL therapy have been variously influenced by several factors including the physiological status of the cells being used, antigen heterogeneity of the tumor cells, complex tumor microenvironment, and the health of the host including the levels of stress hormones. Additionally, host-microbiome has emerged as an important factor that controls the activation status and the longevity of the immune cells. In fact, the impact of secretome, i.e. the soluble substances produced by the gut microbiome, on response to various anti-cancer therapies including immunotherapy is well established. In the current research topic, we envision addressing the role of gut microbiome in influencing the therapeutic outcomes of cellular therapies including CAR-T cell therapy and TIL therapy, especially in the context of solid tumors.

The efficacy of CAR-T cells is extremely limited in solid tumors. Apart from tumor-derived factors such as inhibitory cytokines and immune suppressive cells, host-derived factors such as gut microbiome have started to be identified as an aspect affecting the therapeutic outcomes of immunotherapies. Metabolites produced by gut bacteria, such as short-chain fatty acids (SCFAs), can affect the activity and function of immune cells. These metabolites can either enhance or inhibit the function of immunotherapies, thereby impacting the overall effectiveness of the therapy. However, the full spectrum of effect of gut on CAR-T and other cell-mediated therapies is not defined. Here, we intend to comprehensively address the factors through which the gut microbiome is known to affect immune cells. This would be particularly important to extend our understanding of the mechanisms that influence cell therapies and devise strategies through which their efficacy can be enhanced.

In this research topic, our overall intent is to address the impact of gut microbiome on cell therapies including CAR-T cell and TIL therapy, with a special focus on solid tumors. We welcome original research articles, review articles, and other articles types allowed by the journal.

The major specific themes (questions) being addressed are the following:
1) Impact of the Gut microbiome on the efficacy of CAR-T cells in solid and/or liquid tumors.
2) Gut Microbiome and CAR-T Cell Therapy-Associated Toxicities.
3) Microbiome-Driven Biomarkers for CAR-T Therapy Response
4) Probiotic and Dietary Interventions in Enhancing CAR-T Therapy (role of antibiotics).
5) Gut’s effect on TIL therapy-- speculative based on current literature.
6) Gut Microbiome Modulation to Improve CAR-T Cell Therapy Outcomes

Prof. Vivek Verma is a co-founder of a start-up based in Minneapolis, MN. He also holds a patent for using PKM2 to enhance mitochondrial metabolism in Cd8 T cells. Prof. Leena Hilakivi-Clarke declares no conflicts of interest

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Study Protocol
  • Systematic Review
  • Technology and Code

Keywords: Gut microbiome, Cancer immunotherapy, CAR-T cells, tumors, TILs, Therapy resistance

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Participating Journals

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

Impact

  • 131Topic views
View impact