Molecular mechanisms of neurodegeneration

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and Spinocerebellar ataxias (SCAs), present an enormous medical, social, financial, and scientific challenge. Despite extensive research into the causes of these disorders, progress in the clinic has been limited, and no cures currently exist. Much of the scientific effort has focused on identifying the primary causes of these diseases and developing strategies to target them, such as amyloid accumulation in AD or mutant Huntingtin expression in HD.

This collection aims to provide a platform for experts in the field to share their latest experimental findings or review articles on the molecular mechanisms underlying neurodegeneration, as well as potential therapeutic targets. We are particularly interested in novel mechanisms and therapeutic approaches that have not yet received widespread attention, as well as innovative technological methods for studying neurodegenerative disease pathogenesis.

The specific themes we would like to focus on include:

- Shared molecular mechanisms of pathogenesis in neurodegenerative disorders and aging
- Novel potential therapeutic targets for the treatment of neurodegenerative disorders
- The role of calcium, mitochondrial, and synaptic dysregulation in neurodegenerative disease progression
- New technological approaches for studying neurodegenerative disease pathogenesis.

Keywords: calcium, amyloid, mitochondria, synapse, Alzheimer’s disease, Huntington’s disease

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.