About this Research Topic
Nanopharmacology explores the application of nanotechnology in the delivery of innovative therapeutic and diagnostic agents. Natural-based nanoformulations (i.e., alginate, chitosan, hyaluronic, gelatin, albumin, polyester, polysaccharide particles or even exosomes) are emerging as innovative nano-carriers with potential to enhance delivery while minimizing toxicity. These nanoscale formulations, often characterized by their biodegradable, biocompatible and cytocompatible properties, hold great promise for advancing drug delivery systems and diagnostics. However, translating these nanomedicines into clinical applications presents several challenges, including optimizing pharmacological efficacy, ensuring biopharmaceutical stability, and addressing biosafety concerns. Moreover, their environmental impact and long-term safety remain critical considerations. This Research Topic focuses on exploring these pharmacological, safety, and environmental aspects, fostering the clinical application of natural-based nanomedicines through interdisciplinary research across pharmacology, nanotechnology, toxicology, and related scientific fields.
The Research Topic aims to explore cutting-edge approaches that address the pharmacological, biopharmaceutical, and safety challenges in the development of advanced drug delivery systems from natural-derived materials. The goal is to highlight advancements in biodegradable, biocompatible nanoscale delivery systems and to investigate their preclinical and clinical pharmacokinetics and pharmacodynamics. Moreover, it seeks to present new approaches for drug delivery by leveraging natural-based formulations. The Research Topic promotes the use of computational approaches and advanced modeling tools, such as physiologically-based pharmacokinetic (PBPK) models, to predict therapeutic efficacy and safety. Additionally, it emphasizes the development of eco-friendly and sustainable nanomedicine formulations to mitigate environmental impact. Ultimately, the aim is to facilitate the clinical translation of innovative natural-derived nanomedicines for diagnostic and therapeutic applications.
Key themes include biodegradable, biocompatible and cytocompatible nanoformulations as drug carriers, biosafety and toxicity assessments, green chemistry approaches in nanomedicine development, preclinical and clinical pharmacokinetic/pharmacodynamic studies and translational pharmacology approaches for novel drug nanoformulations. Additionally, we encourage research utilizing physiologically-based pharmacokinetic (PBPK) models to optimize dosing, predict therapeutic outcomes, and assess safety profiles. Submissions addressing regulatory and clinical translation challenges are also welcome. Manuscript types include original research, reviews, mini-reviews, case reports, perspectives, and methodology articles.
The Research Topic aims to explore cutting-edge approaches that address the pharmacological, biopharmaceutical, and safety challenges in the development of advanced drug delivery systems from natural-derived materials. The goal is to highlight advancements in biodegradable, biocompatible nanoscale delivery systems and to investigate their preclinical and clinical pharmacokinetics and pharmacodynamics. Moreover, it seeks to present new approaches for drug delivery by leveraging natural-based formulations. The Research Topic promotes the use of computational approaches and advanced modeling tools, such as physiologically-based pharmacokinetic (PBPK) models, to predict therapeutic efficacy and safety. Additionally, it emphasizes the development of eco-friendly and sustainable nanomedicine formulations to mitigate environmental impact. Ultimately, the aim is to facilitate the clinical translation of innovative natural-derived nanomedicines for diagnostic and therapeutic applications.
Key themes include biodegradable, biocompatible and cytocompatible nanoformulations as drug carriers, biosafety and toxicity assessments, green chemistry approaches in nanomedicine development, preclinical and clinical pharmacokinetic/pharmacodynamic studies and translational pharmacology approaches for novel drug nanoformulations. Additionally, we encourage research utilizing physiologically-based pharmacokinetic (PBPK) models to optimize dosing, predict therapeutic outcomes, and assess safety profiles. Submissions addressing regulatory and clinical translation challenges are also welcome. Manuscript types include original research, reviews, mini-reviews, case reports, perspectives, and methodology articles.
Keywords: Nanopharmacology, natural-based nanomedicines, biodegradable nanoformulations, biosafety and toxicity assessment, translational pharmacology, modeling & simulation, regulatory, advanced drug delivery, nanomaterials, polymeres, polypeptides
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
