Gastric cancer remains a major global health challenge, responsible for significant mortality worldwide. The human gut microbiome and its dysregulation, particularly involving Helicobacter pylori, have been strongly implicated in the genesis, progression, and treatment of gastric cancer. A nuanced understanding of how gut microbiota interact with gastric cancer pathways offers promising avenues for novel preventive and therapeutic strategies. Current research points to the potential for microbiome modulation to play a crucial role in mitigating cancer risk, enhancing treatment efficacy, and improving patient recovery rates, yet many details of these interactions remain unclear.

This Research Topic aims to dissect the complex relationships between the gut microbiome and gastric cancer. Specifically, it seeks to identify microbial profiles linked to cancer risk, elucidate the mechanisms by which microbiota affect cancer progression and treatment responses, and assess the therapeutic potential of microbiome interactions using approaches such as live biotherapeutic products, probiotics, and bioactive substances. Through comprehensive exploration and innovation, this research could lead to groundbreaking strategies to lessen cancer risk and enhance outcomes for gastric cancer patients.

To gather further insights within this pioneering field, we welcome articles addressing, but not limited to, the following themes:

o Detailed analyses of gut microbiota changes associated with gastric cancer and their mechanistic roles in disease risk and progression.
o Studies on Helicobacter pylori and other microbes’ roles in gastric cancer dynamics.
o Investigation into the molecular and cellular pathways through which gut microbiota impact gastric carcinogenesis, including immune response modulation and gastric mucosal alterations.
o Research on the development and effects of probiotics and LBPs in reducing gastric cancer risk or aiding recovery post-treatment.
o Examination of nutritional and bioactive compounds produced by gut microbiota with potential anti-cancer properties.
o Exploration of combining traditional treatments with microbiome-modulating therapies to enhance treatment outcomes.

Researchers are encouraged to submit original research articles, reviews, and mini-reviews that deepen understanding of the gut microbiome's impact on gastric cancer and explore its therapeutic potential. This Research Topic aims to foster interdisciplinary collaborations to propel forward the field of microbiome oncology and improve clinical practices and outcomes for gastric cancer patients.

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Frontiers in Microbiology

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