About this Research Topic
The field of immunometabolism has attracted significant interest in recent years. This is driven by the recognition that cellular metabolism is a fundamental regulator of immune cell activation, differentiation, and function. Recent investigations in the immune system have revealed a dynamic and intricate connection between metabolic programs and the specialized functions they support during immune responses. Specific regulatory pathways linking metabolism and immunity have been characterized, demonstrating the crucial role of metabolism in controlling immune function and the reciprocal relationship between inflammation and metabolism. For instance, T cells must shift towards glycolysis to differentiate into Th1 cells, while regulatory T cells rely more on fatty acid oxidation. In this way, the field of immunometabolism presents a rich area for research to understand how immune responses are modulated by the cell's metabolic state and how metabolic dysregulation can contribute to disease pathogenesis.
This Research Topic aims to provide a comprehensive overview of the current state of knowledge in the field of immunometabolism, with a focus on its implications for human health and disease. We invite contributions that explore the reciprocal relationship between metabolism and immunity, highlighting how perturbations in key metabolic pathways can result in dysregulated immune responses and the development of various pathologies including autoimmune/autoinflammatory disorders and infectious diseases. We welcome the submission of Original Research, Review, Mini-Review, Perspective, and Opinion articles that address these and other related aspects of immunometabolism. The scope of this Research Topic includes, but is not limited to, the following themes:
• Metabolic reprogramming of immune cells in response to environmental cues and inflammatory signals.
• The role of nutrient sensing and signaling pathways in modulating immune cell function.
• The impact of metabolic dysregulation on the development and progression of immune-mediated diseases.
• Therapeutic targeting of immunometabolic pathways for the prevention and treatment of disease.
• Innovative methodologies and technologies for the study of immunometabolism.
• The role of diet in immune cell function.
This Research Topic aims to provide a comprehensive overview of the current state of knowledge in the field of immunometabolism, with a focus on its implications for human health and disease. We invite contributions that explore the reciprocal relationship between metabolism and immunity, highlighting how perturbations in key metabolic pathways can result in dysregulated immune responses and the development of various pathologies including autoimmune/autoinflammatory disorders and infectious diseases. We welcome the submission of Original Research, Review, Mini-Review, Perspective, and Opinion articles that address these and other related aspects of immunometabolism. The scope of this Research Topic includes, but is not limited to, the following themes:
• Metabolic reprogramming of immune cells in response to environmental cues and inflammatory signals.
• The role of nutrient sensing and signaling pathways in modulating immune cell function.
• The impact of metabolic dysregulation on the development and progression of immune-mediated diseases.
• Therapeutic targeting of immunometabolic pathways for the prevention and treatment of disease.
• Innovative methodologies and technologies for the study of immunometabolism.
• The role of diet in immune cell function.
Keywords: Immunometabolism, metabolic reprogramming, non-comunicable diseases, infectious diseases, nutrition, metabolomics and microbiome.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
