About this Research Topic
Lipid metabolism plays a crucial role in the development and function of the nervous system, with its dysregulation implicated in various neurological diseases and mental disorders. The brain’s rich lipid content, for example, neurosteroids, derived from cholesterol, are intricately linked to lipid metabolism, as they not only regulate the synthesis and breakdown of lipids in the brain but also modulate the overall lipid profile, impacting brain function and health. Emerging research demonstrates that imbalances in lipid profiles, such as altered cholesterol and fatty acid metabolism, contribute to the pathogenesis of conditions like epilepsy, Alzheimer’s disease, Parkinson’s disease, and depression. These lipid imbalances affect cellular processes including membrane fluidity, neurotransmitter function, and inflammation, which are critical for cognitive health and mood regulation. This research background highlights the necessity for a deeper understanding of lipid metabolism’s impact on neurological and psychiatric conditions, offering the potential for novel therapeutic targets and early diagnostic markers.
The primary objective of this research is to elucidate the intricate interplay between lipid metabolism and its implications for the progression of neurological diseases and mental disorders. We aim to investigate how the dysregulation of lipid homeostasis contributes to the pathogenesis of conditions. By employing cutting-edge molecular biology techniques, we will identify key lipid species and metabolic pathways disrupted in these disorders. Our research will also explore the potential of modulating lipid metabolism as a therapeutic strategy to ameliorate disease symptoms and halt disease progression. Ultimately, we seek to enhance the understanding of lipid-mediated mechanisms in neurodegenerative and psychiatric conditions, paving the way for novel, targeted interventions.
We welcome manuscript submissions of all types, including original studies, method papers, reviews, perspectives, and case reports. Submissions may encompass clinical trials and basic in vivo or in vitro studies. Themes for submission include, but are not limited to, the following:
- Lipid metabolism in neurological diseases, e.g., epilepsy, Parkinson's disease, Alzheimer’s disease
- Lipid metabolism in mental disorders, e.g., schizophrenia, major depressive disorder, generalized anxiety disorder
- Neurosteroids in brain diseases
- Gut-brain axis in neurological diseases and mental disorders
- Treatment or intervention in neurological diseases and mental disorders through lipid metabolic regulation
- Treatment or intervention on neurological disease and mental disorders through lipid metabolic regulation
The primary objective of this research is to elucidate the intricate interplay between lipid metabolism and its implications for the progression of neurological diseases and mental disorders. We aim to investigate how the dysregulation of lipid homeostasis contributes to the pathogenesis of conditions. By employing cutting-edge molecular biology techniques, we will identify key lipid species and metabolic pathways disrupted in these disorders. Our research will also explore the potential of modulating lipid metabolism as a therapeutic strategy to ameliorate disease symptoms and halt disease progression. Ultimately, we seek to enhance the understanding of lipid-mediated mechanisms in neurodegenerative and psychiatric conditions, paving the way for novel, targeted interventions.
We welcome manuscript submissions of all types, including original studies, method papers, reviews, perspectives, and case reports. Submissions may encompass clinical trials and basic in vivo or in vitro studies. Themes for submission include, but are not limited to, the following:
- Lipid metabolism in neurological diseases, e.g., epilepsy, Parkinson's disease, Alzheimer’s disease
- Lipid metabolism in mental disorders, e.g., schizophrenia, major depressive disorder, generalized anxiety disorder
- Neurosteroids in brain diseases
- Gut-brain axis in neurological diseases and mental disorders
- Treatment or intervention in neurological diseases and mental disorders through lipid metabolic regulation
- Treatment or intervention on neurological disease and mental disorders through lipid metabolic regulation
Keywords: Lipid metabolism, Mechanism, Neurophramacology, Neurological disease, Mental disorder
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
