The interplay between neuronal excitation and inhibition (E/I balance) is central to brain functioning and is a focal point in understanding neurodevelopmental disorders. Disruption in E/I homeostasis has been linked to many neurological conditions, such as Autism Spectrum Disorder (ASD). Social variations, manifested in diverse patterns of social interactions and communication, are a significant phenotype observed in these conditions. With appropriate support, individuals with these social variations can enhance their interactions and communication abilities.
Comprehensive insight into how these imbalances affect social interactions remains fragmented. Recent research leveraging transgenic animal models has begun to uncover the layers of this complex mechanism, yet gaps remain in fully linking molecular and cellular-level disruptions to behavioral outcomes.
The goal of this Research Topic is to further elucidate the mechanisms of neuronal excitation-inhibition homeostasis and its influence on social behaviors using transgenic animal models. We aim to gather research that examines new approaches to assessing the balance between excitation and inhibition in the brain, its impact on brain circuits, and any associated behavioral effects. We strive to foster communication and collaboration among researchers working in this area and promote innovative ideas for therapeutic interventions for neurodevelopmental disorders.
We encourage authors to contribute to this Research Topic on the following themes:
o Investigating E/I homeostasis using transgenic animal models
o Effects of E/I balance disruptions on social interactions and behaviors
o The involvement of specific brain regions or circuits in social adaptations due to E/I imbalances
o Innovative methods for quantifying neuronal excitation and inhibition
o Transgenic animal models to study
E/I homeostasis in neurodevelopment
We particularly welcome original research articles, review articles, and method papers.
Keywords:
Neurological and psychiatric disorders, Autism spectrum disorders, E/I homeostasis, Neuronal excitation-inhibition balance, Social Dynamics, transgenic animal models
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The interplay between neuronal excitation and inhibition (E/I balance) is central to brain functioning and is a focal point in understanding neurodevelopmental disorders. Disruption in E/I homeostasis has been linked to many neurological conditions, such as Autism Spectrum Disorder (ASD). Social variations, manifested in diverse patterns of social interactions and communication, are a significant phenotype observed in these conditions. With appropriate support, individuals with these social variations can enhance their interactions and communication abilities.
Comprehensive insight into how these imbalances affect social interactions remains fragmented. Recent research leveraging transgenic animal models has begun to uncover the layers of this complex mechanism, yet gaps remain in fully linking molecular and cellular-level disruptions to behavioral outcomes.
The goal of this Research Topic is to further elucidate the mechanisms of neuronal excitation-inhibition homeostasis and its influence on social behaviors using transgenic animal models. We aim to gather research that examines new approaches to assessing the balance between excitation and inhibition in the brain, its impact on brain circuits, and any associated behavioral effects. We strive to foster communication and collaboration among researchers working in this area and promote innovative ideas for therapeutic interventions for neurodevelopmental disorders.
We encourage authors to contribute to this Research Topic on the following themes:
o Investigating E/I homeostasis using transgenic animal models
o Effects of E/I balance disruptions on social interactions and behaviors
o The involvement of specific brain regions or circuits in social adaptations due to E/I imbalances
o Innovative methods for quantifying neuronal excitation and inhibition
o Transgenic animal models to study
E/I homeostasis in neurodevelopment
We particularly welcome original research articles, review articles, and method papers.
Keywords:
Neurological and psychiatric disorders, Autism spectrum disorders, E/I homeostasis, Neuronal excitation-inhibition balance, Social Dynamics, transgenic animal models
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.