Advancements in Cell Therapy for Ischemic Heart Disease: Mechanisms, Therapeutic Strategies and Clinical Applications

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 11 April 2025

  2. This Research Topic is still accepting articles.

Background

Ischemic heart disease (IHD) remains the leading cause of mortality globally, despite advancements in pharmacotherapy and revascularization techniques that have improved patient outcomes and reduced mortality rates. However, these conventional treatments fall short in effectively halting the progression of heart failure, necessitating the exploration of novel therapeutic avenues. In recent years, cell therapy has emerged as a promising frontier in regenerative medicine, offering potential solutions for cardiac repair through mechanisms such as paracrine signaling and integration into the heart's cellular network. The exploration of various cell types for heart regeneration has opened new pathways for treatment, yet significant challenges persist. The precise mechanisms by which cell therapy confers benefits are not fully understood, and there is a pressing need to establish optimal therapeutic protocols, including the manufacturing and delivery of cellular or molecular products. Addressing these gaps is crucial for advancing the field and improving patient outcomes.
This research topic aims to foster a comprehensive dialogue on the latest advancements in cell therapy for ischemic heart disease. We seek to explore the cellular and molecular mechanisms that underpin cardiac repair and regeneration, investigate novel cell types and engineering techniques, and evaluate innovative cell transplantation modalities and assess the safety, efficacy, and translational potential of cell therapies. By addressing these areas, we aim to answer critical questions and test hypotheses that could lead to more effective regenerative therapies for IHD.

To gather further insights in the realm of stem cell and regenerative therapies for ischemic heart disease, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of cell and molecular products for cardiac repair and regeneration.
- Physiological cardiac regeneration in lower vertebrates and neonatal mammals.
- Advances in the design and manufacture of cell and molecular products for heart regeneration.
- Protocols for heart regenerative therapy.
- Analysis of the feasibility, safety, and effectiveness of new regenerative therapy in animal models and clinical trials.
- Biomarkers and predictive models for prognosis in regenerative therapies.
- The impact of organ crosstalk on cardiac health and regeneration.
- Lifestyle influences and risk factors in regenerative outcomes.
- Innovative techniques for in vivo cell tracing and cell fate control after transplantation.

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Keywords: cell therapy, cardiac regeneration, ischemic heart disease

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