About this Research Topic
The coronary microcirculation is a crucial component of maintaining cardiac function, playing a key role in regulating myocardial blood flow to meet the heart's metabolic demands. In recent years, microvascular dysfunction has been closely associated with poor prognosis in various cardiovascular diseases. The pathophysiological mechanisms of coronary microcirculation disorders are complex, involving endothelial dysfunction, abnormal vascular smooth muscle responses, inflammatory reactions, microvascular remodeling, and oxidative stress. Current research focuses on identifying and quantifying these microcirculatory abnormalities through imaging techniques, hemodynamic assessments, and biomarker detection. New therapeutic strategies, including pharmacological interventions, lifestyle modifications, and physical therapy approaches, are being explored to improve clinical outcomes. Meanwhile, the biopsychosocial medical model is becoming increasingly important in the treatment of microvascular dysfunction. However, many challenges remain regarding the fundamental mechanisms, risk factors, diagnostic strategies, and therapeutic approaches for coronary microcirculation, which require further research and exploration.
This research topic aims to provide a platform for the exchange and presentation of the latest advances in the diagnosis, treatment, and basic research of coronary microcirculation disorders. We encourage authors to submit innovative studies on coronary microcirculation, particularly those that elucidate the molecular and cellular mechanisms of microvascular dysfunction, explore non-traditional risk factors (especially the correlation with emotional disorders), develop new diagnostic tools and methods, and investigate novel therapeutic strategies. By bringing together these cutting-edge research findings, this research topic aims to deepen the understanding of the role of coronary microcirculation in cardiovascular health and disease and to promote the development of effective diagnostic and therapeutic approaches.
We invite authors to submit original research and review articles on the following topics:
• Pathophysiological mechanisms of coronary microcirculation disorders: including the roles of endothelial function, inflammation, oxidative stress, and microvascular remodeling.
• Non-traditional risk factors: such as emotional disorders and gut microbiota dysbiosis in relation to microcirculatory dysfunction.
• Innovative diagnostic techniques: such as non-invasive imaging, hemodynamic assessments, microcirculation function tests, and novel biomarker studies.
• Clinical management strategies for microvascular angina (MVA) and ischemia with non-obstructive coronary arteries (INOCA).
• Pharmacological and non-pharmacological approaches to improve coronary microcirculation: including anti-inflammatory, antithrombotic, vasodilatory, reperfusion strategies, and physical therapy approaches.
• The relationship between coronary microcirculation and systemic metabolic disorders (e.g., diabetes, hypertension).
• Basic mechanistic studies of microcirculation dysfunction using animal models and in vitro experimental systems.
This research topic aims to provide a platform for the exchange and presentation of the latest advances in the diagnosis, treatment, and basic research of coronary microcirculation disorders. We encourage authors to submit innovative studies on coronary microcirculation, particularly those that elucidate the molecular and cellular mechanisms of microvascular dysfunction, explore non-traditional risk factors (especially the correlation with emotional disorders), develop new diagnostic tools and methods, and investigate novel therapeutic strategies. By bringing together these cutting-edge research findings, this research topic aims to deepen the understanding of the role of coronary microcirculation in cardiovascular health and disease and to promote the development of effective diagnostic and therapeutic approaches.
We invite authors to submit original research and review articles on the following topics:
• Pathophysiological mechanisms of coronary microcirculation disorders: including the roles of endothelial function, inflammation, oxidative stress, and microvascular remodeling.
• Non-traditional risk factors: such as emotional disorders and gut microbiota dysbiosis in relation to microcirculatory dysfunction.
• Innovative diagnostic techniques: such as non-invasive imaging, hemodynamic assessments, microcirculation function tests, and novel biomarker studies.
• Clinical management strategies for microvascular angina (MVA) and ischemia with non-obstructive coronary arteries (INOCA).
• Pharmacological and non-pharmacological approaches to improve coronary microcirculation: including anti-inflammatory, antithrombotic, vasodilatory, reperfusion strategies, and physical therapy approaches.
• The relationship between coronary microcirculation and systemic metabolic disorders (e.g., diabetes, hypertension).
• Basic mechanistic studies of microcirculation dysfunction using animal models and in vitro experimental systems.
Keywords: Coronary microcirculation, Microvascular dysfunction, Pathophysiological mechanisms, Diagnostic techniques, Therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
