About this Research Topic
Autoimmune diseases comprise more than 80 different diseases that have in common a burden on health systems and are of unknown etiology. In general, in most countries, autoimmune diseases affect an increasing number of people, with women between the ages of 20 and 40 being the most affected by most of these diseases.
Although the etiology is poorly understood, it is known that genetic and environmental factors influence the onset of autoimmune diseases. The reaction of autoreactive T lymphocytes or autoantibodies, whether physiologically or pathologically induced, are the hallmarks of the immune response in autoimmune diseases. It is already known that controlling adaptive immunity results in better disease outcomes. It is also known that the intestinal microbiota directly influences the body's immune response. Therefore, understanding and managing these variables could improve the prognosis of the disease.
However, despite all the accumulated knowledge and available medications, most of these diseases have no cure. Thus, developing new therapeutic approaches in the form of plant-derived formulations, drug repositioning, nanostructured formulations, and alternative therapies, which present better results by controlling autoreactivity with fewer side effects and lower costs, are highly appreciated by the pharmaceutical industry and, mainly by patients.
Therefore, this Research Topic aims to encompass recent advances in developing drugs and alternative therapies that regulate adaptive immunity or intestinal microbiota in autoimmune diseases.
We invite researchers to contribute to this collection with original research articles, reviews, mini-reviews, and clinical trials covering, but not limited to, the latest and most significant discoveries on:
• Unveil the mechanism of action of plant-derived formulations for treating autoimmune diseases.
• Repositioning drugs for autoimmune diseases.
• Role of physical exercises in regulating autoimmune diseases.
• Role of physical exercises in regulating the efficacy of therapies for autoimmune diseases.
• Exploring the barriers to developing and implementing new therapeutic strategies for autoimmune diseases.
• Understanding the interplay between the gut microbiota and the immune system and how it influences the efficacy and response to new drug formulations for autoimmune diseases.
• Analyzing the effects of probiotics in the immune system regulation in autoimmune diseases.
Although the etiology is poorly understood, it is known that genetic and environmental factors influence the onset of autoimmune diseases. The reaction of autoreactive T lymphocytes or autoantibodies, whether physiologically or pathologically induced, are the hallmarks of the immune response in autoimmune diseases. It is already known that controlling adaptive immunity results in better disease outcomes. It is also known that the intestinal microbiota directly influences the body's immune response. Therefore, understanding and managing these variables could improve the prognosis of the disease.
However, despite all the accumulated knowledge and available medications, most of these diseases have no cure. Thus, developing new therapeutic approaches in the form of plant-derived formulations, drug repositioning, nanostructured formulations, and alternative therapies, which present better results by controlling autoreactivity with fewer side effects and lower costs, are highly appreciated by the pharmaceutical industry and, mainly by patients.
Therefore, this Research Topic aims to encompass recent advances in developing drugs and alternative therapies that regulate adaptive immunity or intestinal microbiota in autoimmune diseases.
We invite researchers to contribute to this collection with original research articles, reviews, mini-reviews, and clinical trials covering, but not limited to, the latest and most significant discoveries on:
• Unveil the mechanism of action of plant-derived formulations for treating autoimmune diseases.
• Repositioning drugs for autoimmune diseases.
• Role of physical exercises in regulating autoimmune diseases.
• Role of physical exercises in regulating the efficacy of therapies for autoimmune diseases.
• Exploring the barriers to developing and implementing new therapeutic strategies for autoimmune diseases.
• Understanding the interplay between the gut microbiota and the immune system and how it influences the efficacy and response to new drug formulations for autoimmune diseases.
• Analyzing the effects of probiotics in the immune system regulation in autoimmune diseases.
Keywords: Autoimmune Diseases, intestinal microbiota, adaptive immune regulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
