About this Research Topic
Neurological disorders are a significant global issue, affecting one in four people at some point in their lives . While their exact causes are largely unknown, recent studies suggest that both genetic and epigenetic factors play a role in their development. Epigenetics involves the interaction between genes and the environment, leading to heritable changes in gene expression. Recent research into neurodevelopmental disorders has pinpointed genes that control chromatin as significant risk factors. These genes regulate the expression of developmental genes in the brain, influencing the development of connections between different types of neurons and networks that drive the differentiation of neurons and their responses to activity.
This research topic aims to provide a platform for addressing the interplay between chromatin marks in brain development and disease through the lens of chromatin modifiers. We welcome emerging insights into the intimate crosstalk between specific histone modification states, DNA methylation, and gene expression during mammalian brain development. We encourage submissions describing how these insights have arisen from recent studies of histone lysine methyl transferases (KMTase), lysine demethylases, acetyltransferases (HATs), deacetylases (HDACs), and DNA methyl transferases (DNMT) mutants in the mouse and human induced pluripotent stem cells (iPSCs), focusing on their impact in neurodevelopment.
We are seeking submissions from the scientific community, including original research, review articles, rapid communications, and clinical case studies. We are interested in topics such as:
How chromatin modifiers contribute to neurodevelopment and how their dysregulation affects brain disorders.
New technical approaches for identifying the role of chromatin modifiers in controlling gene expression, chromatin topology, splicing, RNA-chromatin crosstalk, and brain development.
Evidence for mechanisms involving chromatin modifiers' role in neural physiology.
Studies on clinically relevant cell types in neurodevelopmental disorders that aim to identify 'druggable' targets with disrupted expression underlying their etiology.
Advances and challenges in the development of therapies targeting chromatin modifiers in neurological diseases and neurodevelopmental disorders
This groundbreaking research initiative is focused on assembling a thorough and unified catalog of chromatin modifiers. The aim is to pave the way for revolutionary discoveries and to facilitate the development of innovative therapeutic interventions within this field.
This research topic aims to provide a platform for addressing the interplay between chromatin marks in brain development and disease through the lens of chromatin modifiers. We welcome emerging insights into the intimate crosstalk between specific histone modification states, DNA methylation, and gene expression during mammalian brain development. We encourage submissions describing how these insights have arisen from recent studies of histone lysine methyl transferases (KMTase), lysine demethylases, acetyltransferases (HATs), deacetylases (HDACs), and DNA methyl transferases (DNMT) mutants in the mouse and human induced pluripotent stem cells (iPSCs), focusing on their impact in neurodevelopment.
We are seeking submissions from the scientific community, including original research, review articles, rapid communications, and clinical case studies. We are interested in topics such as:
How chromatin modifiers contribute to neurodevelopment and how their dysregulation affects brain disorders.
New technical approaches for identifying the role of chromatin modifiers in controlling gene expression, chromatin topology, splicing, RNA-chromatin crosstalk, and brain development.
Evidence for mechanisms involving chromatin modifiers' role in neural physiology.
Studies on clinically relevant cell types in neurodevelopmental disorders that aim to identify 'druggable' targets with disrupted expression underlying their etiology.
Advances and challenges in the development of therapies targeting chromatin modifiers in neurological diseases and neurodevelopmental disorders
This groundbreaking research initiative is focused on assembling a thorough and unified catalog of chromatin modifiers. The aim is to pave the way for revolutionary discoveries and to facilitate the development of innovative therapeutic interventions within this field.
Keywords: chromatin, epigenetics, neurodevelopmental disorders, histone modification, iPSCs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
