About this Research Topic
Cancer immunotherapy has emerged as a groundbreaking approach in the treatment of various malignancies, yet growing evidence highlights significant sex disparities in treatment outcomes. This Research Topic aims to explore the underlying biological mechanisms contributing to these differences between males and females. The focus will be on understanding the roles of sex hormones, genetic variations, and other biological factors that influence the efficacy and safety of immunotherapies across different cancer types.
Recent studies suggest that sex hormones such as estrogen and testosterone may modulate immune responses, potentially impacting the effectiveness of treatments like checkpoint inhibitors and CAR T-cell therapy. Additionally, genetic differences, including those related to immune system genes, may further contribute to the observed disparities in therapeutic outcomes.
In this Research Topic, we seek to delve into the complex interplay of these factors, examining how they might affect the tumor microenvironment, immune cell infiltration, and overall response to treatment. By investigating these mechanisms, we aim to uncover novel strategies to optimize immunotherapy for both sexes, potentially leading to more personalized and effective treatment approaches.
This Research Topic welcomes submissions of original research, reviews, short communications, and clinical studies that address, but are not limited to, the following areas:
--The impact of sex hormones on the efficacy of cancer immunotherapies.
--Genetic and molecular differences in immune response between males and females.
--Sex-specific variations in the tumor microenvironment and their influence on immunotherapy outcomes.
--Novel therapeutic strategies to mitigate sex disparities in cancer treatment.
We encourage contributions from researchers across disciplines, including cancer biology, immunology, genetics, and clinical oncology, to foster a comprehensive understanding of sex disparities in cancer immunotherapy.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Recent studies suggest that sex hormones such as estrogen and testosterone may modulate immune responses, potentially impacting the effectiveness of treatments like checkpoint inhibitors and CAR T-cell therapy. Additionally, genetic differences, including those related to immune system genes, may further contribute to the observed disparities in therapeutic outcomes.
In this Research Topic, we seek to delve into the complex interplay of these factors, examining how they might affect the tumor microenvironment, immune cell infiltration, and overall response to treatment. By investigating these mechanisms, we aim to uncover novel strategies to optimize immunotherapy for both sexes, potentially leading to more personalized and effective treatment approaches.
This Research Topic welcomes submissions of original research, reviews, short communications, and clinical studies that address, but are not limited to, the following areas:
--The impact of sex hormones on the efficacy of cancer immunotherapies.
--Genetic and molecular differences in immune response between males and females.
--Sex-specific variations in the tumor microenvironment and their influence on immunotherapy outcomes.
--Novel therapeutic strategies to mitigate sex disparities in cancer treatment.
We encourage contributions from researchers across disciplines, including cancer biology, immunology, genetics, and clinical oncology, to foster a comprehensive understanding of sex disparities in cancer immunotherapy.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords: Sex Disparities in Cancer, Novel therapeutic strategies and sex disparities, Sex-specific variations in the tumor microenvironment, sex immune response, sex hormones in cancer, cancer immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
