About this Research Topic
Neurotransmitters, once only associated with neuronal signaling, have been increasingly found to play crucial roles in immunomodulation, both in the brain and peripheral tissues. The effects of neurotransmitters on immune cells are diverse, ranging from modulation of cytokine production and phagocytosis to the development of antibody responses to regulation of cell migration, proliferation and differentiation. Recent advances in neurobiology and immunology have provides new approaches to investigate neurotransmitter-mediated immunomodulation at the molecular, cellular and system levels. These are important for unraveling the mechanisms underlying various physiological and pathological conditions, including autoimmune disorders, cancer and inflammation.
Despite the growing evidence of neurotransmitters as immune modulators, the precise mechanisms and signaling pathways by which neurotransmitters regulate immunity and inflammation remain incompletely understood. Our goal is to compile cutting-edge research on this topic to provide a comprehensive overview of the current state of knowledge and stimulate further investigations into the exciting field of neurotransmitter-driven immunomodulation.
This research topic will focus on multifaceted effects of neurotransmitters on immune cell functions. We encourage contributions that employ various approaches addressing the following themes.
1. Presence and activity of neurotransmitter receptor and signaling pathways in various immune cell types that mediate innate and adaptive immune responses.
2. Impact of neurotransmitters on immune cell activation, differentiation, metabolism, migration and effector functions during homeostasis
3. Role of neurotransmitters mediated changes in immune function in the development of inflammation, cancers and other pathogenic conditions.
4. Effects of neurotransmitters on cytokine production and release and signaling pathways mediating these processes.
5. Novel methodologies for studying neurotransmitter-immune cell interactions.
6. Potential utility of neurotransmitter receptors and signaling pathways as therapeutic targets in immune-related disorders.
We are interested in the following types of manuscripts: original research articles, reviews and mini-reviews, method papers, perspective articles and short communications.
The Topic editors declare that they have no conflicts of interest to declare in relation to the editorship of this collection.
Despite the growing evidence of neurotransmitters as immune modulators, the precise mechanisms and signaling pathways by which neurotransmitters regulate immunity and inflammation remain incompletely understood. Our goal is to compile cutting-edge research on this topic to provide a comprehensive overview of the current state of knowledge and stimulate further investigations into the exciting field of neurotransmitter-driven immunomodulation.
This research topic will focus on multifaceted effects of neurotransmitters on immune cell functions. We encourage contributions that employ various approaches addressing the following themes.
1. Presence and activity of neurotransmitter receptor and signaling pathways in various immune cell types that mediate innate and adaptive immune responses.
2. Impact of neurotransmitters on immune cell activation, differentiation, metabolism, migration and effector functions during homeostasis
3. Role of neurotransmitters mediated changes in immune function in the development of inflammation, cancers and other pathogenic conditions.
4. Effects of neurotransmitters on cytokine production and release and signaling pathways mediating these processes.
5. Novel methodologies for studying neurotransmitter-immune cell interactions.
6. Potential utility of neurotransmitter receptors and signaling pathways as therapeutic targets in immune-related disorders.
We are interested in the following types of manuscripts: original research articles, reviews and mini-reviews, method papers, perspective articles and short communications.
The Topic editors declare that they have no conflicts of interest to declare in relation to the editorship of this collection.
Keywords: Immune cells, Neurotransmitters, Immune function, cytokine production, migration, immunemodulation, pharmacology, T cells, B cells, NK cells, monocytes and macrophages, dendritic cells, microglia, neutrophils, mast cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
