Molecular Mechanisms and Pathophysiology of Dry Eye Disease and Meibomian Gland Dysfunction

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 17 March 2025 | Manuscript Submission Deadline 5 July 2025

  2. This Research Topic is still accepting articles.

Background

Dry Eye Disease (DED) and Meibomian Gland Dysfunction (MGD) are among the most prevalent ocular conditions, detrimentally affecting countless individuals’ quality of life globally. MGD is especially highlighted for its significant role as a root cause of DED. Despite numerous studies, the detailed molecular mechanisms and pathophysiological processes leading to DED and MGD remain inadequately defined. Recognizing the intricate roles of inflammation, oxidative stress, neurogenic influences, and their complex interactions is essential. Additionally, the connection between systemic conditions and localized ocular symptoms complicates the understanding of their etiologies. Given these complexities, there is an urgent need for comprehensive research utilizing both animal and in vitro models. Such studies are vital to dissect the intricate molecular interplays and to pave the way for breakthrough therapeutic solutions.

The primary goal of this research topic is to delve deeper into the unexplored molecular pathways and pathophysiological processes of DED and MGD. By advancing our understanding through rigorous scientific inquiry, we aim to foster the development of innovative therapeutic strategies that could revolutionize the management and treatment of these widespread ocular diseases.

We invite submissions of original research, methods, reviews, mini-reviews, case reports, perspectives, clinical trials, and brief research reports. We specifically encourage the submission of exceptional work that has not been previously published or is not currently being reviewed by other journals or peer-reviewed conferences. To further enhance our understanding and treatment of these complex conditions, we encourage submissions on a broad spectrum of related themes, particularly:
o Molecular Mechanisms: Focus will be on unraveling the roles of inflammatory mediators, oxidative stress, and neurogenic factors. Research here aims to decode how these elements precipitate and influence the progression of DED and MGD, targeting the discovery of novel therapeutic avenues.
o Pathophysiology: Research will illuminate the complex interactions between systemic health and local ocular conditions, contributing to DED and MGD. This theme seeks to dissect these multifactorial relationships, paving the way for preemptive and therapeutic solutions.
o Therapeutic Interventions: Initiative in this area will explore cutting-edge treatment modalities and drug development. Studies will seek to enhance the efficacy of interventions and improve clinical outcomes for individuals afflicted by these conditions.
o Models: Emphasis will be placed on developing and refining animal and in vitro models that accurately simulate the human pathologies of DED and MGD. These models are essential for delving into molecular mechanisms and enabling the thorough testing of potential treatments.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Clinical Trial
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Dry Eye Disease, Meibomian Gland Dysfunction, Inflammation, in vitro models, pathophysiology

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