Significant advancements have been made in targeted cancer therapy in recent years, yet the challenge of overcoming resistance to these treatments in solid tumors persists. The tumor microenvironment (TME) is increasingly recognized as a key player in tumor development and progression. However, the complex regulatory networks within the TME that contribute to resistance against targeted therapies are still not fully understood. Research focused on disrupting abnormal regulatory pathways in solid tumors and targeting the TME to enhance anti-tumor responses is crucial. Additionally, implementing patient stratification strategies based on novel biomarkers is vital for developing innovative therapeutic approaches. A deeper understanding of these processes will aid in the development of more effective targeted therapies for precision oncology.
This topic will primarily focus on recent advancements in molecular biology, immunology, and pharmacology related to targeted therapies for the treatment of solid tumors and the improvement of the TME. The objectives of this research topic include developing innovative strategies for targeted therapy to enhance the treatment of solid cancers through the improvement of the TME. This may involve the identification of new molecular targets in the TME, the exploration of combination therapy approaches to improve the TME, and the determination of the novel molecular mechanisms underlying established or new targeted therapies, particularly their impact on the cancer immune microenvironment. The objectives of this research topic also include presenting the clinical application and evaluation of new targeted therapies for interventions in patients with solid tumors, such as implementing novel patient stratification strategies based on existing or new biomarkers in the TME. Ultimately, this research topic aims to introduce new opportunities for targeted therapies and their unique molecular mechanisms to enhance the treatment of solid tumors through improving the TME.
We invite submissions on the progress in elucidating molecular mechanisms or targeted therapies for solid tumors or microenvironments. The topic aims to highlight research relevant to oncologists, immunologists, and drug developers. The research topic will include but not be limited to the followings:
Remodeling the tumor microenvironment
Enzyme-instructed self-assembly (EISA) therapy
Solid tumor microenvironment
Molecular mechanisms of tumor-stroma interactions
Targeted therapies related to tumor or microenvironment
Biomarkers for tumor microenvironment assessment
Keywords:
Microenvironments, Targeted Therapy, Molecular Mechanisms, Tumor, Solid
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Significant advancements have been made in targeted cancer therapy in recent years, yet the challenge of overcoming resistance to these treatments in solid tumors persists. The tumor microenvironment (TME) is increasingly recognized as a key player in tumor development and progression. However, the complex regulatory networks within the TME that contribute to resistance against targeted therapies are still not fully understood. Research focused on disrupting abnormal regulatory pathways in solid tumors and targeting the TME to enhance anti-tumor responses is crucial. Additionally, implementing patient stratification strategies based on novel biomarkers is vital for developing innovative therapeutic approaches. A deeper understanding of these processes will aid in the development of more effective targeted therapies for precision oncology.
This topic will primarily focus on recent advancements in molecular biology, immunology, and pharmacology related to targeted therapies for the treatment of solid tumors and the improvement of the TME. The objectives of this research topic include developing innovative strategies for targeted therapy to enhance the treatment of solid cancers through the improvement of the TME. This may involve the identification of new molecular targets in the TME, the exploration of combination therapy approaches to improve the TME, and the determination of the novel molecular mechanisms underlying established or new targeted therapies, particularly their impact on the cancer immune microenvironment. The objectives of this research topic also include presenting the clinical application and evaluation of new targeted therapies for interventions in patients with solid tumors, such as implementing novel patient stratification strategies based on existing or new biomarkers in the TME. Ultimately, this research topic aims to introduce new opportunities for targeted therapies and their unique molecular mechanisms to enhance the treatment of solid tumors through improving the TME.
We invite submissions on the progress in elucidating molecular mechanisms or targeted therapies for solid tumors or microenvironments. The topic aims to highlight research relevant to oncologists, immunologists, and drug developers. The research topic will include but not be limited to the followings:
Remodeling the tumor microenvironment
Enzyme-instructed self-assembly (EISA) therapy
Solid tumor microenvironment
Molecular mechanisms of tumor-stroma interactions
Targeted therapies related to tumor or microenvironment
Biomarkers for tumor microenvironment assessment
Keywords:
Microenvironments, Targeted Therapy, Molecular Mechanisms, Tumor, Solid
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.