Progress in Molecular Mechanisms and Targeted Therapies for Solid Tumor Microenvironments

The field of oncology has witnessed significant advancements in targeted cancer therapy, yet the persistent challenge of resistance in solid tumors remains a critical issue. The tumor microenvironment (TME) is increasingly recognized as a pivotal factor in tumor development and progression, influencing the efficacy of targeted therapies. Despite the progress, the intricate regulatory networks within the TME that contribute to therapeutic resistance are not fully understood. Recent studies have highlighted the importance of disrupting abnormal regulatory pathways and targeting the TME to enhance anti-tumor responses. However, there is a pressing need for research that delves deeper into these complex interactions and identifies novel biomarkers for patient stratification. Such insights are essential for developing innovative therapeutic approaches that can improve the precision and effectiveness of targeted therapies in oncology.

This research topic aims to develop innovative strategies for targeted therapy to enhance the treatment of solid cancers through the improvement of the TME. The objectives include identifying new molecular targets within the TME, exploring combination therapy approaches, and determining novel molecular mechanisms underlying both established and new targeted therapies. Additionally, the research seeks to present the clinical application and evaluation of these therapies, focusing on novel patient stratification strategies based on biomarkers within the TME. Ultimately, the goal is to introduce new opportunities for targeted therapies and their unique molecular mechanisms to enhance the treatment of solid tumors by improving the TME.

To gather further insights into the molecular mechanisms and targeted therapies for solid tumor microenvironments, we welcome articles addressing, but not limited to, the following themes:
- Remodeling the tumor microenvironment
- Enzyme-instructed self-assembly (EISA) therapy
- Solid tumor microenvironment
- Molecular mechanisms of tumor-stroma interactions
- Targeted therapies related to tumor or microenvironment
- Biomarkers for tumor microenvironment assessment

Keywords: Microenvironments, Targeted Therapy, Molecular Mechanisms, Tumor, Solid

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.