About this Research Topic
We are currently witnessing a new era in cancer therapeutics marked by an increasing number of treatment options for breast cancer. The development of agents with improved specificity and the establishment of an optimized therapeutic approach hold promise for better management and survival outcomes for breast cancer patients. In this Research topic, our goal is to investigate the new target, biomarker, and underlying mechanisms related to breast cancer chemotherapy resistance. Exploration of novel therapeutic drugs and approaches to improve breast cancer chemotherapy efficacy is highly welcome. We invite contributors to address, but not limited to the following specific themes:
● Exploration and verification of predictive and/or prognostic biomarkers to address chemotherapy decisions or to overcome challenges and limitations of current breast cancer chemotherapy.
● New targets associated with chemotherapy resistance mechanism: intracellular drug concentrations decrease, DNA damage repair, cell death inhibition, cancer stem cell, the epithelial-mesenchymal transition (EMT), and epigenetic modifications.
● Translational research in screening and evaluating cytokines, antibodies, small molecules, or natural products alone or combined with chemotherapy drugs to improve treatment efficacy.
● Developing novel drug delivery systems (such as nanoparticles) to improve the therapeutic effectiveness and safety profile of traditional chemotherapeutic agents.
● Prospective or retrospective clinical trial data, real-world evidence, and comparative studies of breast cancer chemotherapy or combined with target therapy and immunotherapy.
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: Breast Cancer, Chemotherapy, Biomarkers, Resistance, Nanoparticles
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.