About this Research Topic

Background

The mechanical, biological, and computer sciences are complicated aspects of organ/tissue-on-a-chip strategic design. The integration of this innovative technology is becoming increasingly important as regenerative medicine advances. Utilizing the capabilities of microfluidic systems, this novel technique recreates, on a tiny scale, the intricate microenvironments of human organs and tissues. With the aid of this cutting-edge technology, clinical translational research will proceed more quickly and easily.

Organ/tissue-on-a-chip technology and regenerative medicine, when combined, create new opportunities to learn about cell behavior, tissue formation, environmental regulations, and disease progression. Through the precise replication of the physiological parameters of specific organs or tissues, these microscale platforms offer researchers significant insights into the complex interplay among cells, biomaterials, and therapeutic interventions.

Using organs and tissues on a chip also greatly reduces the need for animal testing, as advanced microfluidic systems can mimic the intricate microenvironments found in mammals.

In addition to accelerating drug research and testing procedures, this development has enormous potential for personalized medicine. The ability to establish organ-specific microenvironments allows for the customization of regeneration techniques to meet each patient's unique needs, resulting in more effective and targeted treatments. It will revolutionize current precision medicine by using the patient’s own tissues. Research on tumors and cancer also stands to benefit significantly. This cutting-edge technology can precisely construct therapies and enable optimal drug selections during screening.

The integration of organ/tissue-on-a-chip technology is increasingly recognized as having a significant impact on regenerative medicine. This synergy represents a major advancement in our pursuit to fully realize the potential of regenerative medicine, from improving our understanding of biological responses to enhancing the development of regenerative therapeutics.

Key areas of focus within this Research Topic include:

Stem Cells: Leveraging stem cell technology within organ-on-a-chip platforms to study differentiation and tissue regeneration.

Tissue Regeneration: Exploring the mechanisms and conditions that promote tissue repair and growth in accurately replicated human tissue environments.

Disease Modeling: Developing sophisticated disease models to study pathophysiology and therapeutic responses within organ-on-a-chip systems.

Drug Screenings: Utilizing high-throughput screening methods in microfluidic platforms to accelerate drug discovery and testing.

Cancer Studies: Investigating tumor biology, metastasis, and personalized cancer treatment using advanced organ-on-a-chip technology.

By addressing these critical areas, this Research Topic will advance our understanding and development of next-generation medical treatments. We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Organ-on-a-Chip, Tissue-on-a-Chip, OOAC, TOAC, Microfluidic Systems, Stem Cells, Tissue Regeneration, Disease Modeling, Drug Screenings, Metastasis, Tumor Biology, Personalized Cancer Treatment

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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