About this Research Topic
Recent advancements in molecular biology, genomics, and immunology have provided renewed insights into cancer mechanisms, leading to the identification of novel therapeutic targets. These insights include the understanding of genetic mutations, epigenetic modifications, tumor microenvironment, and immune evasion strategies that cancer cells employ to survive and proliferate. Targeted therapies, immunotherapies, and personalized medicine have emerged as promising approaches to improving cancer treatment outcomes. Despite these advances, challenges such as postoperative recurrence, drug resistance, tumor heterogeneity, and limited efficacy of current therapies in certain cancer types highlight the need for continued research.
The critical problems in cancer therapy include the development of cancer recurrence and resistance to chemotherapies, targeted therapies, and immunotherapies. While these treatments have shown significant initial success, many patients eventually experience relapse due to the cancer cell's ability to adapt and develop resistance mechanisms. This problem is compounded by the heterogeneous nature of tumors, where different cells within the same tumor may respond differently to treatment.
Ultimately, this Research Topic seeks to contribute to the development of more durable and personalized cancer treatments. By understanding and circumventing the mechanisms of recurrence and drug resistance, it may be possible to significantly improve patient outcomes, reduce relapse rates, and extend survival in those affected by various forms of cancer.
We invite submissions that explore a broad range of themes within the realm of cancer mechanisms and therapy, including but not limited to:
- Genetic and epigenetic factors in cancer progression and resistance.
- Tumor microenvironment and its role in therapeutic outcomes.
- Mechanisms of immune evasion and strategies to overcome them.
- Development and effectiveness of novel targeted therapies.
- Personalized medicine approaches in cancer treatment.
- Comparative studies on the efficacy of current cancer therapies.
We welcome original research articles, reviews, and case reports relevant to these themes. Manuscripts should provide new insights or significant advancements in understanding or addressing cancer mechanisms and therapeutic strategies. By fostering a comprehensive understanding of the challenges and opportunities in cancer therapy, this Research Topic aims to guide future research and clinical practices toward more effective solutions.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The critical problems in cancer therapy include the development of cancer recurrence and resistance to chemotherapies, targeted therapies, and immunotherapies. While these treatments have shown significant initial success, many patients eventually experience relapse due to the cancer cell's ability to adapt and develop resistance mechanisms. This problem is compounded by the heterogeneous nature of tumors, where different cells within the same tumor may respond differently to treatment.
Ultimately, this Research Topic seeks to contribute to the development of more durable and personalized cancer treatments. By understanding and circumventing the mechanisms of recurrence and drug resistance, it may be possible to significantly improve patient outcomes, reduce relapse rates, and extend survival in those affected by various forms of cancer.
We invite submissions that explore a broad range of themes within the realm of cancer mechanisms and therapy, including but not limited to:
- Genetic and epigenetic factors in cancer progression and resistance.
- Tumor microenvironment and its role in therapeutic outcomes.
- Mechanisms of immune evasion and strategies to overcome them.
- Development and effectiveness of novel targeted therapies.
- Personalized medicine approaches in cancer treatment.
- Comparative studies on the efficacy of current cancer therapies.
We welcome original research articles, reviews, and case reports relevant to these themes. Manuscripts should provide new insights or significant advancements in understanding or addressing cancer mechanisms and therapeutic strategies. By fostering a comprehensive understanding of the challenges and opportunities in cancer therapy, this Research Topic aims to guide future research and clinical practices toward more effective solutions.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: cancer mechanisms, drug resistance, targeted therapies, immune evasion, personalized medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
