About this Research Topic
Aortic aneurysm is a life-threatening disease characterized by permanent localized dilation of the aorta (a diameter 50% greater than an adjacent normal aortic segment), resulting in catastrophic aortic rupture and sudden death. Currently, endovascular stenting and open surgery are the mainstays of treatment for aortic aneurysm, and no medication has been approved by the Food and Drug Administration (FDA) to induce regression or slow aneurysm growth and restrain the risk of rupture. Clarifying the potential molecular mechanisms and identifying novel and efficient therapeutic targets are therefore of great importance.
This Research Topic aims to deepen our understanding of molecular mechanisms underlying aortic aneurysmal diseases. By integrating single-cell RNA sequencing, Spatial Transcriptomics, lineage tracing, and cellular/molecular biology, we seek to uncover fundamental processes by which genetic and acquired factors induce or exacerbate aortic aneurysmal diseases. The insights gained from this field could lead to novel therapeutic strategies, offering new avenues for the prevention, recognition and treatment of aortic aneurysmal diseases.
This Research Topic focuses on the recent advances, detailed experimental protocols, challenges, and application prospects in this area. We would particularly encourage submissions that take new omics approaches to uncover novel mechanisms of aneurysmal diseases. We welcome basic research, clinical studies, and reviews. Authors may submit various article types, including Original Research, Brief Research Reports, Reviews, Mini-Reviews, and Systematic Reviews.
This Research Topic aims to deepen our understanding of molecular mechanisms underlying aortic aneurysmal diseases. By integrating single-cell RNA sequencing, Spatial Transcriptomics, lineage tracing, and cellular/molecular biology, we seek to uncover fundamental processes by which genetic and acquired factors induce or exacerbate aortic aneurysmal diseases. The insights gained from this field could lead to novel therapeutic strategies, offering new avenues for the prevention, recognition and treatment of aortic aneurysmal diseases.
This Research Topic focuses on the recent advances, detailed experimental protocols, challenges, and application prospects in this area. We would particularly encourage submissions that take new omics approaches to uncover novel mechanisms of aneurysmal diseases. We welcome basic research, clinical studies, and reviews. Authors may submit various article types, including Original Research, Brief Research Reports, Reviews, Mini-Reviews, and Systematic Reviews.
Keywords: Cardiovascular disease, Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Marfan Syndrome, VSMC
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
