About this Research Topic

Background

Urological malignancies, encompassing bladder cancer, prostate cancer, kidney cancer, and others, are among the most prevalent neoplasms impacting human health. Recent years have witnessed rapid advancements in systemic oncology treatments for these malignancies, including surgical approaches, immunotherapy, targeted therapy, and chemotherapy. Notably, progress in precision medicine and immunotherapy has introduced new tools for the treatment of urological cancers, and combination therapies have emerged as promising strategies for better tumor control, offering new treatment options for patients with metastatic tumors and significantly prolonging patient survival and improving quality of life.

However, treatment resistance in urological tumors cannot be ignored, which could profoundly impact patient survival and prognosis. The complexity of urological tumors necessitates diverse therapeutic approaches and options. These tumors exhibit varying therapeutic responses and resistance to different treatments, requiring extensive research into therapeutic resistance, particularly for common urinary tract tumors such as prostate and bladder cancer. Effective strategies to overcome treatment resistance in urological tumors necessitate a comprehensive, individualized approach. This approach should be tailored to each patient's clinical features, tumor tissue characteristics, and genetic profile. Continuous monitoring of tumor progression and timely adjustments in treatment strategies are crucial for prolonging patient survival and enhancing the quality of life.

In this Research Topic, we try to bring together great insights into the treatment resistance in urological tumors. We invite contributions across various article types, including original research, reviews, and mini-reviews, that explore the molecular and cellular mechanisms of treatment resistance in chemotherapy, immunotherapy, targeted drug therapy, and surgical treatment for urological tumors and explore strategies to overcome treatment resistance, with the ultimate goal of improving therapeutic efficacy, patient survival, and prognosis.

Please note: Manuscripts that include only bioinformatic or computational analyses of public genomic or transcriptomic databases without accompanying validation (independent cohort or in vitro or in vivo bio-validation) are outside the scope of this section and will not be accepted as part of this research topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Urological Tumour, Treatment Resistance, Chemotherapy, Immunotherapy, Surgical Interventions, Robotic Surgery, Bladder Cancer, Prostate Cancer, Kidney Cancer, Testicular Cancer, Renal Pelvis Cancer

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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