About this Research Topic
The skeletal system provides the body with many functions like support, protection, and mobility. Homeostasis is crucial for the skeletal system. Bone tissue is in a dynamic balance state, known as bone remodeling with the balance of osteoblast and osteoclast activities. Perturbations to this homeostasis due to aging or diseases can lead to osteoporosis. During bone defect repair, modulating the osteoblast-osteoclast balance is essential for optimal bone regeneration. Additionally, aging, injury and excessive mechanical stress can lead to the degeneration and damage of cartilage, intervertebral discs, tendon and rotator cuff. The perturbations of homeostasis and microenvironment in joints could further trigger inflammatory responses, possibly resulting in diseases like arthritis. Furthermore, the skeletal system plays a significant role in overall body homeostasis. Recent studies have demonstrated the crosstalk between the skeletal system and other organs and tissues, such as muscles, bone marrow, liver, brain, and intestines.
Many skeletal-related diseases and conditions such as osteoporosis, osteoarthritis, bone and cartilage regeneration, mechanical injury, as well as infection and degenerative process, are all intimately connected with skeletal homeostasis and its perturbations. In this Research Topic, we hope that researchers will further uncover the complex mechanisms that maintain skeletal system homeostasis and the surrounding environment. We encourage exploration of the communication inside and outside the skeletal system under various conditions such as disease, exercise, and aging. These related findings will hopefully promote therapeutic and translational research in skeletal diseases.
This Research Topic welcomes different manuscript types, including but not limited to Original Research Articles, Methods, Reviews, and Mini Reviews, focusing on basic research, translational therapies, and clinical studies. We invite contributions that are comprehensive nature on the following themes:
1. The regulatory mechanisms of bone remodeling and cartilage homeostasis.
2. Perturbations in the bone and joint microenvironment during diseases such as osteoarthritis, osteoporosis, bone defects, disc degeneration, and infections.
3. Pathogenesis or treatment of tendon or rotator cuff injury.
4. The benefits of exercise and other active interventions on the skeletal system's environment.
5. The processes of regeneration and interventions for skeletal-related diseases.
6. The crosstalk of homeostasis and disruptions between the skeletal system and other tissues and organs.
7. Advanced treatments, including stem cell therapies and bioengineering strategies, aimed at modifying the environment and homeostasis in skeletal-related diseases.
8. Clinical research related to the homeostatic balance of the skeletal system.
Many skeletal-related diseases and conditions such as osteoporosis, osteoarthritis, bone and cartilage regeneration, mechanical injury, as well as infection and degenerative process, are all intimately connected with skeletal homeostasis and its perturbations. In this Research Topic, we hope that researchers will further uncover the complex mechanisms that maintain skeletal system homeostasis and the surrounding environment. We encourage exploration of the communication inside and outside the skeletal system under various conditions such as disease, exercise, and aging. These related findings will hopefully promote therapeutic and translational research in skeletal diseases.
This Research Topic welcomes different manuscript types, including but not limited to Original Research Articles, Methods, Reviews, and Mini Reviews, focusing on basic research, translational therapies, and clinical studies. We invite contributions that are comprehensive nature on the following themes:
1. The regulatory mechanisms of bone remodeling and cartilage homeostasis.
2. Perturbations in the bone and joint microenvironment during diseases such as osteoarthritis, osteoporosis, bone defects, disc degeneration, and infections.
3. Pathogenesis or treatment of tendon or rotator cuff injury.
4. The benefits of exercise and other active interventions on the skeletal system's environment.
5. The processes of regeneration and interventions for skeletal-related diseases.
6. The crosstalk of homeostasis and disruptions between the skeletal system and other tissues and organs.
7. Advanced treatments, including stem cell therapies and bioengineering strategies, aimed at modifying the environment and homeostasis in skeletal-related diseases.
8. Clinical research related to the homeostatic balance of the skeletal system.
Keywords: Bone Remodeling Balance, Bone Microenvironment, Osteoarthritis, Osteoporosis, Bone Defect, Aging and Degeneration, Tendon, Rotator Cuff, Skeletal Crosstalk, bone marrow, bone and cartilage
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
