Exploring Extracellular Vesicle Signaling and Mitochondrial Metabolism in Aging and Aging-Related Diseases

Aging and aging-related diseases have become a central focus in scientific research due to the increasing social and economic implications of a growing elderly population worldwide. The quest to understand the mechanisms underlying the pathophysiology of aging and to develop innovative strategies to mitigate its impacts is more pressing than ever. Historically, extracellular vesicles were understood as membrane-enclosed nanovesicles secreted by nearly all cell types, playing roles in various cellular processes, while mitochondria were primarily recognized for their role in ATP production, essential for eukaryotic life. However, recent studies have highlighted the significance of extracellular vesicles and mitochondria as pivotal players in aging and aging-related diseases. These components are now seen as crucial in diagnostics and as potential pathways for therapeutic interventions in age-related pathologies. Despite these advancements, there remains a need for deeper investigation into their roles and interactions, as well as the development of novel diagnostic and therapeutic approaches.

This research topic aims to deepen our understanding of extracellular vesicle signaling and mitochondrial metabolism within various cellular processes and their implications in the pathology of aging and aging-related diseases. Specifically, the objective is to provide a comprehensive and updated overview of how these elements contribute to aging and related diseases, and to explore innovative diagnostic and therapeutic methods. The research will address key questions such as the roles of extracellular vesicles in the aging microenvironment and the potential of these vesicles and mitochondrial functions as therapeutic targets.

To gather further insights into the complex interplay between extracellular vesicle signaling and mitochondrial metabolism in aging and aging-related diseases, we welcome articles addressing, but not limited to, the following themes:
- Roles of extracellular vesicles in the aging microenvironment and aging-related diseases
- The therapeutic potential of extracellular vesicles in aging and aging-related diseases
- Extracellular vesicles as a source of aging and aging-related disease biomarkers
- Mitochondrial dysfunction as a hallmark for aging and aging-related diseases
- Therapeutic strategies for mitochondrial dysfunction