Aging and aging-related diseases have emerged at the forefront of scientific research due to the growing social and economic costs associated with the increasingly aging global population. Meanwhile, there is a growing demand for exploring the mechanisms underlying the pathophysiology of aging and developing new strategies to address the burden of aging. In the past, extracellular vesicles were membrane-enclosed nanovesicles secreted by almost all cell types and were widely accepted to be involved in various cellular processes, while mitochondria were best known as the sites for the production of respiratory ATP and were essential for eukaryotic life. In recent years, extracellular vesicles and mitochondria have become recognized not merely as bioactive mediators and energy suppliers but also as emerging key actors in aging and aging-related diseases. Notably, extracellular vesicles and mitochondria are increasingly recognized as new frontiers in diagnostics and as means to identify pathways for therapeutic intervention in a variety of age-related pathologies.
In this research topic, we hope to further our understanding of extracellular vesicle signaling and mitochondrial metabolism in various cellular processes and in the pathology of many diseases. Particularly, this topic aims to provide a broad and updated overview of the role of extracellular vesicle signaling and mitochondrial metabolism in aging and aging-related diseases, as well as new diagnostic and therapeutic methods. We expect original research articles and reviews on potential subtopics including, but not limited to, the following:
• Roles of extracellular vesicles in the aging microenvironment and aging-related diseases
• The therapeutic potential of extracellular vesicles in aging and aging-related diseases
• Extracellular vesicles as a source of aging and aging-related disease biomarkers
• Mitochondrial dysfunction as a hallmark for aging and aging-related diseases
• Therapeutic strategies for mitochondrial dysfunction
Keywords:
extracellular Vesicle, mitochondria, aging, aging-related diseases, aging biomaker
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Aging and aging-related diseases have emerged at the forefront of scientific research due to the growing social and economic costs associated with the increasingly aging global population. Meanwhile, there is a growing demand for exploring the mechanisms underlying the pathophysiology of aging and developing new strategies to address the burden of aging. In the past, extracellular vesicles were membrane-enclosed nanovesicles secreted by almost all cell types and were widely accepted to be involved in various cellular processes, while mitochondria were best known as the sites for the production of respiratory ATP and were essential for eukaryotic life. In recent years, extracellular vesicles and mitochondria have become recognized not merely as bioactive mediators and energy suppliers but also as emerging key actors in aging and aging-related diseases. Notably, extracellular vesicles and mitochondria are increasingly recognized as new frontiers in diagnostics and as means to identify pathways for therapeutic intervention in a variety of age-related pathologies.
In this research topic, we hope to further our understanding of extracellular vesicle signaling and mitochondrial metabolism in various cellular processes and in the pathology of many diseases. Particularly, this topic aims to provide a broad and updated overview of the role of extracellular vesicle signaling and mitochondrial metabolism in aging and aging-related diseases, as well as new diagnostic and therapeutic methods. We expect original research articles and reviews on potential subtopics including, but not limited to, the following:
• Roles of extracellular vesicles in the aging microenvironment and aging-related diseases
• The therapeutic potential of extracellular vesicles in aging and aging-related diseases
• Extracellular vesicles as a source of aging and aging-related disease biomarkers
• Mitochondrial dysfunction as a hallmark for aging and aging-related diseases
• Therapeutic strategies for mitochondrial dysfunction
Keywords:
extracellular Vesicle, mitochondria, aging, aging-related diseases, aging biomaker
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.