About this Research Topic
Background: Bacterial extracellular vesicles (EVs) play significant roles in intercellular communication, pathogenesis, and immune modulation. These vesicles can carry a variety of biomolecules, including proteins, lipids, and genetic material, and have been implicated in the transfer of antibiotic-resistance genes (ARGs). The growing concern of antimicrobial resistance (AMR) poses a severe threat to global health, as it compromises the effectiveness of antibiotics and leads to more challenging-to-treat infections. The dual role of bacterial EVs in both promoting and potentially mitigating AMR through novel therapeutic strategies makes them a critical focus of current research.
Goal: This research topic aims to explore the dualistic nature of bacterial extracellular vesicles in the context of antimicrobial resistance. It seeks to elucidate how these vesicles contribute to the spread of resistance genes among bacterial populations, thereby exacerbating the AMR crisis. Simultaneously, the topic will investigate the potential of bacterial EVs as novel therapeutic tools, either through vaccine development, as drug delivery systems, or as components of innovative treatment strategies. By examining both the etiopathogenic mechanisms and therapeutic possibilities, this collection of research will provide a comprehensive understanding of the multifaceted roles of bacterial EVs in the landscape of infectious diseases.
Scope: Researchers and clinicians are invited to contribute original research articles, reviews, clinical trials, case reports, and perspectives that delve into the diverse roles of bacterial EVs in AMR. Submissions may cover a range of topics, including but not limited to the molecular mechanisms of ARG transfer via EVs, the impact of EVs on bacterial pathogenicity, and innovative therapeutic approaches leveraging EVs. Studies exploring the structural and functional properties of bacterial EVs, their interaction with host immune systems, the potential use of EVs in vaccine development, the role of EVs in polymicrobial diseases, and their potential therapeutic value are particularly welcome. Authors should ensure that their submissions provide novel insights, are methodologically sound, and contribute significantly to the understanding of bacterial EVs and AMR.
Goal: This research topic aims to explore the dualistic nature of bacterial extracellular vesicles in the context of antimicrobial resistance. It seeks to elucidate how these vesicles contribute to the spread of resistance genes among bacterial populations, thereby exacerbating the AMR crisis. Simultaneously, the topic will investigate the potential of bacterial EVs as novel therapeutic tools, either through vaccine development, as drug delivery systems, or as components of innovative treatment strategies. By examining both the etiopathogenic mechanisms and therapeutic possibilities, this collection of research will provide a comprehensive understanding of the multifaceted roles of bacterial EVs in the landscape of infectious diseases.
Scope: Researchers and clinicians are invited to contribute original research articles, reviews, clinical trials, case reports, and perspectives that delve into the diverse roles of bacterial EVs in AMR. Submissions may cover a range of topics, including but not limited to the molecular mechanisms of ARG transfer via EVs, the impact of EVs on bacterial pathogenicity, and innovative therapeutic approaches leveraging EVs. Studies exploring the structural and functional properties of bacterial EVs, their interaction with host immune systems, the potential use of EVs in vaccine development, the role of EVs in polymicrobial diseases, and their potential therapeutic value are particularly welcome. Authors should ensure that their submissions provide novel insights, are methodologically sound, and contribute significantly to the understanding of bacterial EVs and AMR.
Keywords: Bacterial Extracellular Vesicles (BEVs), Antimicrobial Resistance (AMR), Novel Therapeutic Approaches, Infection Pathogenesis, Intercellular Communication
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
