About this Research Topic
Bone regeneration is a complex physiological process crucial for healing fractures, repairing defects, and treating conditions like osteoporosis. Traditional approaches, including surgical grafts and implants, often face challenges such as limited availability of donor material, risk of infection, and suboptimal integration with the host tissue. In recent years, drug delivery systems (DDS) especially nanodrug delivery have emerged as a promising alternative, offering targeted, controlled, and sustained release of therapeutic agents to enhance bone regeneration.
Delivery systems for bone regeneration are designed to deliver bioactive molecules such as growth factors, cytokines, or drugs directly to the site of injury or defect. These systems aim to create an optimal microenvironment that promotes cellular proliferation, differentiation, and matrix production, all of which are essential for new bone formation. Various DDS platforms have been developed, including nanoparticles, hydrogels, scaffolds, and injectable carriers. Each of these platforms can be engineered to release their therapeutic cargo in a controlled manner, either through degradation, diffusion, or response to specific biological triggers.
One of the most notable applications of DDS in bone regeneration is the delivery of bone morphogenetic proteins (BMPs), which are potent inducers of osteogenesis. Encapsulating BMPs in biocompatible carriers allows for localized delivery, minimizing systemic side effects and enhancing the therapeutic outcome. Similarly, the use of osteoinductive agents and anti-inflammatory drugs in DDS can accelerate healing and reduce complications.
Moreover, advances in nanotechnology have enabled the development of multifunctional DDS that can simultaneously deliver multiple agents, provide structural support, and monitor the regeneration process. These innovations hold great potential for improving the efficacy and safety of bone regeneration therapies. Therefore, this Research Topic aims to provide a comprehensive, contemporary collection of research focusing on exploring drug delivery systems for bone regeneration.
We welcome Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, Data notes, and technical notes, but are not limited to the following:
• Research focuses on developing nanoparticles that can carry and release osteogenic drugs at the site of bone injury, enhancing localized bone growth.
• Studies that have shown that hydrogels can encapsulate and release growth factors, provide a hydrated environment that mimics natural tissue, aiding in bone repair and regeneration.
• Research where nanoparticles can be engineered to specifically target bone tissues, improving the efficiency and precision of drug delivery for bone regeneration.
• Research that demonstrates the use of biocompatible and biodegradable scaffolds combined with DDS to provide structural support.
Delivery systems for bone regeneration are designed to deliver bioactive molecules such as growth factors, cytokines, or drugs directly to the site of injury or defect. These systems aim to create an optimal microenvironment that promotes cellular proliferation, differentiation, and matrix production, all of which are essential for new bone formation. Various DDS platforms have been developed, including nanoparticles, hydrogels, scaffolds, and injectable carriers. Each of these platforms can be engineered to release their therapeutic cargo in a controlled manner, either through degradation, diffusion, or response to specific biological triggers.
One of the most notable applications of DDS in bone regeneration is the delivery of bone morphogenetic proteins (BMPs), which are potent inducers of osteogenesis. Encapsulating BMPs in biocompatible carriers allows for localized delivery, minimizing systemic side effects and enhancing the therapeutic outcome. Similarly, the use of osteoinductive agents and anti-inflammatory drugs in DDS can accelerate healing and reduce complications.
Moreover, advances in nanotechnology have enabled the development of multifunctional DDS that can simultaneously deliver multiple agents, provide structural support, and monitor the regeneration process. These innovations hold great potential for improving the efficacy and safety of bone regeneration therapies. Therefore, this Research Topic aims to provide a comprehensive, contemporary collection of research focusing on exploring drug delivery systems for bone regeneration.
We welcome Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, Data notes, and technical notes, but are not limited to the following:
• Research focuses on developing nanoparticles that can carry and release osteogenic drugs at the site of bone injury, enhancing localized bone growth.
• Studies that have shown that hydrogels can encapsulate and release growth factors, provide a hydrated environment that mimics natural tissue, aiding in bone repair and regeneration.
• Research where nanoparticles can be engineered to specifically target bone tissues, improving the efficiency and precision of drug delivery for bone regeneration.
• Research that demonstrates the use of biocompatible and biodegradable scaffolds combined with DDS to provide structural support.
Keywords: Bone regeneration, Nano drug delivery system, drug delivery systems, hydrogels, scaffolds
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
