About this Research Topic
Chronic kidney disease (CKD) represents a significant global public health challenge, characterized by the gradual decline in renal function over time. Metabolism, aging, oxidative stress, and alterations in gut microbiota composition have been pivotal factors influencing CKD progression, with dysregulation in these processes exacerbating the condition. Understanding the intricate interplay among these factors and their impact on CKD progression is imperative for devising effective preventive and therapeutic strategies. Through comprehensive analysis of cytological, clinical, and lifestyle factors, researchers endeavor to unveil novel insights that can inform tailored approaches to mitigate CKD risk and enhance outcomes for affected individuals. The critical issue at hand revolves around the pressing necessity to deepen our comprehension of the molecular mechanisms underlying renal injury and dysfunction, with the overarching objective of pioneering innovative therapeutic interventions to ameliorate patient outcomes. Both acute and chronic kidney diseases present formidable challenges to healthcare systems worldwide, precipitating elevated morbidity and mortality rates. Recent strides in cellular and molecular biology have illuminated the intricate pathophysiology of kidney ailments, underscoring the pivotal roles of inflammation, oxidative stress, and fibrosis in disease progression. By elucidating these underlying mechanisms, we can pinpoint potential therapeutic targets for intervention.
This research topic aims to explore the latest breakthroughs in understanding the pathogenesis of acute and chronic kidney diseases, with a particular emphasis on pioneering methodologies such as stem cell therapy, precision medicine, and targeted drug delivery. By fostering collaboration between basic scientists and clinicians, our goal is to expedite the translation of research findings into clinical practice, thereby enhancing the management and treatment of kidney disease patients. Specific questions to be addressed include how novel therapeutic strategies can be effectively integrated into existing treatment paradigms and what molecular targets offer the most promise for future interventions.
To gather further insights in the molecular mechanisms and innovative therapeutic strategies in nephrology, we welcome articles addressing, but not limited to, the following themes:
- The role of oxidative stress and inflammation in CKD progression.
- Advances in stem cell therapy for renal repair and regeneration.
- Precision medicine approaches tailored to individual CKD patient profiles.
- The impact of gut microbiota on kidney health and disease.
- Novel drug delivery systems targeting renal tissues.
- Interdisciplinary collaborations between researchers and clinicians to enhance CKD management.
This research topic aims to explore the latest breakthroughs in understanding the pathogenesis of acute and chronic kidney diseases, with a particular emphasis on pioneering methodologies such as stem cell therapy, precision medicine, and targeted drug delivery. By fostering collaboration between basic scientists and clinicians, our goal is to expedite the translation of research findings into clinical practice, thereby enhancing the management and treatment of kidney disease patients. Specific questions to be addressed include how novel therapeutic strategies can be effectively integrated into existing treatment paradigms and what molecular targets offer the most promise for future interventions.
To gather further insights in the molecular mechanisms and innovative therapeutic strategies in nephrology, we welcome articles addressing, but not limited to, the following themes:
- The role of oxidative stress and inflammation in CKD progression.
- Advances in stem cell therapy for renal repair and regeneration.
- Precision medicine approaches tailored to individual CKD patient profiles.
- The impact of gut microbiota on kidney health and disease.
- Novel drug delivery systems targeting renal tissues.
- Interdisciplinary collaborations between researchers and clinicians to enhance CKD management.
Keywords: molecular mechanisms, kidney disease, oxidative stress, therapeutic strategies, precision medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
